Kinase profiling results of kinases in KIF 3LQ8A_88Z (MET, PDB code: 3LQ8, chain A)
Template Kinase: MET
Template inhibitor: AZD_1152HQPA

19 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C C
MYO3ASTE         
DDR1TK         
DDR2TK         
PTK2BTK         
IGF1RTK         
INSRTK         
INSRRTK         
METTK         
MUSKTK         
LCKTK         
TEKTK         
TIE1TK         
NTRK1TK         
NTRK2TK         
NTRK3TK         
FLT1TK         
FLT4TK         
KDRTK         
RIPK1TKL         

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
DDR2TK  
FLT1TK  
FLT4TK  
IGF1RTK  
INSRTK  
INSRRTK  
KDRTK  
LCKTK  
METTK  
MUSKTK  
NTRK1TK  
NTRK2TK  
NTRK3TK  
PTK2BTK  
TEKTK