Kinase profiling results of kinases in KIF 2OIDA_ANP (IRAK4, PDB code: 2OID, chain A)
Template Kinase: IRAK4
Template inhibitor: Phosphoaminophosphonic Acid-Adenylate Ester

 21 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
CHEK2CAMK
CDK2CMGC
CDK9CMGC
AURKAOther
PLK1Other
STK24STE
MAP2K1STE
ABL1TK
TNK2TK
ERBB3TK
FGFR1TK
FGFR2TK
IGF1RTK
INSRTK
METTK
RETTK
SRCTK
HCKTK
LCKTK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
CHEK2CAMK
CDK2CMGC
CDK9CMGC
AURKAOther
PLK1Other
MAP2K1STE
STK24STE
ABL1TK
FGFR1TK
FGFR2TK
HCKTK
IGF1RTK
INSRTK
LCKTK
METTK
RETTK
SRCTK
TNK2TK
IRAK4TKL