Kinase profiling results of kinases in KIF 3MJ1A_614 (ITK, PDB code: 3MJ1, chain A)
Template Kinase: ITK
Template inhibitor: 7-(4-Methylpiperazin-1-Yl)-4-[(5-Methyl-1h-Pyrazol-3-Yl)amino]-2-(Propan-2-Yl)phthalazin-1(2h)-One

 13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
CDK2CMGC  
PLK2Other  
TNK2TK  
JAK2TK  
JAK3TK  
KITTK  
LCKTK  
SYKTK  
BTKTK  
ITKTK  
TEKTK  
FLT4TK  
KDRTK  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CDK2CMGC 
PLK2Other 
BTKTK 
FLT4TK 
ITKTK 
JAK2TK 
JAK3TK 
KDRTK 
KITTK 
LCKTK 
SYKTK 
TEKTK 
TNK2TK