Kinase profiling results of kinases in KIF 3EYHA_IZA (JAK1, PDB code: 3EYH, chain A)
Template Kinase: JAK1
Template inhibitor: Pyridone 6

21 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
DAPK1CAMK
CDK2CMGC
CDK4CMGC
AURKAOther
TNK2TK
ALKTK
LTKTK
PTK2TK
FERTK
FGFR2TK
JAK1TK
JAK2TK
JAK3TK
RETTK
ROS1TK
FYNTK
HCKTK
NTRK2TK
NTRK3TK
MAP3K7TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
CHEK1CAMK    
DAPK1CAMK    
CDK2CMGC    
CDK4CMGC    
AURKAOther    
ALKTK    
FERTK    
FGFR2TK    
FYNTK    
HCKTK    
JAK1TK    
JAK2TK    
JAK3TK    
LTKTK    
NTRK2TK    
NTRK3TK    
PTK2TK    
RETTK    
ROS1TK    
TNK2TK    
MAP3K7TKL