Kinase profiling results of kinases in KIF 2XA4A_AZ5 (JAK2, PDB code: 2XA4, chain A)
Template Kinase: JAK2
Template inhibitor: AZD1480, AZD 1480

15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
CDK2CMGC 
CDK4CMGC 
GSK3BCMGC 
AURKBOther 
EGFRTK 
FGFR3TK 
JAK2TK 
JAK3TK 
MUSKTK 
PDGFRBTK 
RETTK 
LCKTK 
NTRK1TK 
NTRK2TK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK4CMGC     
GSK3BCMGC     
AURKBOther     
EGFRTK     
FGFR3TK     
JAK2TK     
JAK3TK     
LCKTK     
MUSKTK     
NTRK1TK     
NTRK2TK     
PDGFRBTK     
RETTK