Kinase profiling results of kinases in KIF 3JY9A_JZH (JAK2, PDB code: 3JY9, chain A)
Template Kinase: JAK2
Template inhibitor: atropisomer 1

 11 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
NUAK1CAMK
CDK2CMGC
CDK5CMGC
AURKAOther
AURKBOther
ALKTK
EGFRTK
JAK2TK
JAK3TK
LCKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
NUAK1CAMK
CDC2CMGC
CDC2CMGC
CDK2CMGC
CDK5CMGC
AURKAOther
AURKBOther
ALKTK
EGFRTK
JAK2TK
JAK3TK
LCKTK