Kinase profiling results of kinases in KIF 3KCKA_3KC (JAK2, PDB code: 3KCK, chain A)
Template Kinase: JAK2
Template inhibitor: L-779450

 13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CDK4CMGC
GSK3BCMGC
DDR1TK
DDR2TK
EGFRTK
JAK2TK
METTK
FRKTK
SRCTK
PTK6TK
BRAFTKL
RAF1TKL
RIPK2TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CDK4CMGC
GSK3BCMGC
DDR2TK
EGFRTK
FRKTK
JAK2TK
METTK
PTK6TK
SRCTK
BRAFTKL
RAF1TKL
RIPK2TKL