Kinase profiling results of kinases in KIF 3LXLA_IZA (JAK3, PDB code: 3LXL, chain A)
Template Kinase: JAK3
Template inhibitor: Pyridone 6

 30 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
PKN1AGC
MARK2CAMK
MARK4CAMK
NUAK1CAMK
STK17ACAMK
CDK2CMGC
AURKAOther
AURKBOther
AURKCOther
TNK2TK
ALKTK
LTKTK
CSKTK
FERTK
FGFR2TK
JAK1TK
JAK2TK
JAK3TK
RETTK
ROS1TK
FYNTK
HCKTK
NTRK2TK
NTRK3TK
MAP3K7TKL
BRAFTKL
RIPK2TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
GRK6AGC    
PDPK1AGC    
PKN1AGC    
PRKCAAGC    
MARK2CAMK    
MARK4CAMK    
NUAK1CAMK    
STK17ACAMK    
CDK2CMGC    
AURKAOther    
AURKBOther    
AURKCOther    
ALKTK    
CSKTK    
FERTK    
FGFR2TK    
FYNTK    
HCKTK    
JAK1TK    
JAK2TK    
JAK3TK    
LTKTK    
NTRK2TK    
NTRK3TK    
RETTK    
ROS1TK    
TNK2TK    
BRAFTKL    
MAP3K7TKL    
RIPK2TKL