Kinase profiling results of kinases in KIF 3PJCA_PJC (JAK3, PDB code: 3PJC, chain A)
Template Kinase: JAK3
Template inhibitor: 3-(1h-Indol-3-Yl)-4-[2-(4-Oxopiperidin-1-Yl)-5-(Trifluoromethyl)pyrimidin-4-Yl]-1h-Pyrrole-2,5-Dione

8 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
PRKCQAGC   
PRKCHAGC   
GSK3BCMGC   
JAK1TK   
JAK2TK   
JAK3TK   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
PRKCAAGC  
PRKCBAGC  
PRKCBAGC  
PRKCHAGC  
PRKCQAGC  
GSK3BCMGC  
JAK1TK  
JAK2TK  
JAK3TK