Kinase profiling results of kinases in KIF 1FGIA_SU1 (FGFR1, PDB code: 1FGI, chain A)
Template Kinase: FGFR1
Template inhibitor: Indolin-2-one deriv. 9a

25 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
NUAK1CAMK
CDK2CMGC
AURKAOther
AURKBOther
AURKCOther
MAP4K5STE
MAP4K4STE
ALKTK
LTKTK
EGFRTK
PTK2TK
FGFR1TK
JAK3TK
CSF1RTK
KITTK
PDGFRBTK
RETTK
SRCTK
ZAP70TK
NTRK1TK
NTRK2TK
NTRK3TK
FLT4TK
KDRTK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
NUAK1CAMK   
CDK2CMGC   
AURKAOther   
AURKBOther   
AURKCOther   
MAP4K4STE   
MAP4K5STE   
ALKTK   
CSF1RTK   
EGFRTK   
FGFR1TK   
FLT4TK   
JAK3TK   
KDRTK   
KITTK   
LTKTK   
NTRK1TK   
NTRK2TK   
NTRK3TK   
PDGFRBTK   
PTK2TK   
RETTK   
SRCTK   
ZAP70TK   
IRAK4TKL