Kinase profiling results of kinases in KIF 2GMXA_877 (MAPK8, PDB code: 2GMX, chain A)
Template Kinase: MAPK8
Template inhibitor: N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE

 3 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
MAPK10CMGC
MAPK8CMGC
MAPK9CMGC

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
MAPK10CMGC 
MAPK8CMGC 
MAPK9CMGC