Kinase profiling results of kinases in KIF 2XK4A_OL2 (NEK2, PDB code: 2XK4, chain A)
Template Kinase: NEK2
Template inhibitor: 4-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]-2-Ethoxybenzoic Acid

 8 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CHEK1CAMK
MAPKAPK23
PIM1CAMK
CHEK2CAMK
NEK1Other
NEK2Other
PTK2TK
SRCTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CHEK1CAMK 
CHEK2CAMK 
MAPKAPK2CAMK 
PIM1CAMK 
NEK1Other 
NEK2Other 
PTK2TK 
SRCTK