Kinase profiling results of kinases in KIF 2XNMA_WGZ (NEK2, PDB code: 2XNM, chain A)
Template Kinase: NEK2
Template inhibitor: benzimidazole thiophene carboxamide, 24

 12 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
DAPK3CAMK 
PRKD3CAMK 
CDK2CMGC 
IKBKEOther 
NEK1Other 
NEK5Other 
NEK2Other 
NEK9Other 
PLK1Other 
PLK2Other 
PLK3Other 
SLKSTE 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
DAPK3CAMK
PRKD3CAMK
CDK2CMGC
IKBKEOther
NEK1Other
NEK2Other
PLK1Other
PLK2Other
PLK3Other
SLKSTE