Kinase profiling results of kinases in KIF 2RKUA_R78 (PLK1, PDB code: 2RKU, chain A)
Template Kinase: PLK1
Template inhibitor: BI 2536

 37 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C
DMPKAGC        
GRK7AGC        
CAMK2BCAMK        
CAMK2DCAMK        
CAMK2GCAMK        
HUNKCAMK        
MGC421053        
DAPK1CAMK        
DAPK2CAMK        
DAPK3CAMK        
PHKG1CAMK        
PHKG2CAMK        
PRKD1CAMK        
PRKD2CAMK        
PRKD3CAMK        
CHEK2CAMK        
CDK2CMGC        
CDK5CMGC        
GSK3BCMGC        
MAPK14CMGC        
AURKAOther        
AURKBOther        
CAMKK1Other        
CAMKK2Other        
NEK3Other        
NEK2Other        
EIF2AK2Other        
PLK1Other        
PLK2Other        
PLK3Other        
SLKSTE        
STK10STE        
TNK1TK        
PTK2TK        
INSRTK        
HCKTK        
IRAK4TKL        

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
DMPKAGC     
GRK7AGC     
CAMK2BCAMK     
CAMK2DCAMK     
CAMK2GCAMK     
CHEK2CAMK     
DAPK1CAMK     
DAPK2CAMK     
DAPK3CAMK     
PHKG1CAMK     
PHKG2CAMK     
PRKD1CAMK     
PRKD2CAMK     
PRKD3CAMK     
CDK2CMGC     
CDK5CMGC     
GSK3BCMGC     
MAPK14CMGC     
AURKAOther     
AURKBOther     
CAMKK1Other     
CAMKK2Other     
NEK2Other     
NEK3Other     
PLK1Other     
PLK2Other     
PLK3Other     
SLKSTE     
STK10STE     
HCKTK     
INSRTK     
PTK2TK     
IRAK4TKL