Kinase profiling results of kinases in KIF 2BROA_DF2 (CHEK1, PDB code: 2BRO, chain A)
Template Kinase: CHEK1
Template inhibitor: pyrrolopyrimidine compound 7

 29 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PRKCDAGC
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
CHEK1CAMK
STK33CAMK
PIM1CAMK
PIM2CAMK
CHEK2CAMK
CDK2CMGC
CDK3CMGC
CDK4CMGC
CDK5CMGC
CDK9CMGC
PCTK1CMGC
MAPK1CMGC
MAPK10CMGC
MAPK14CMGC
AURKAOther
CAMKK2Other
CHUKOther
PLK1Other
PLK3Other
PAK4STE
FYNTK
SRCTK
NTRK2TK
NTRK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
PRKCAAGC     
PRKCDAGC     
RPS6KA1AGC     
RPS6KA2AGC     
CHEK1CAMK     
CHEK2CAMK     
PIM1CAMK     
PIM2CAMK     
STK33CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK3CMGC     
CDK4CMGC     
CDK5CMGC     
CDK9CMGC     
MAPK1CMGC     
MAPK10CMGC     
MAPK14CMGC     
AURKAOther     
CAMKK2Other     
CHUKOther     
PLK1Other     
PLK3Other     
PAK4STE     
FYNTK     
NTRK2TK     
NTRK3TK     
SRCTK