Kinase profiling results of kinases in KIF 2FGIA_PD1 (FGFR1, PDB code: 2FGI, chain A)
Template Kinase: FGFR1
Template inhibitor: Pyrido[2,3-d]pyrimidine 104

24 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
CDK2CMGC    
MAPK14CMGC    
AURKAOther    
PLK1Other    
PLK2Other    
PLK3Other    
ABL1TK    
TNK2TK    
EGFRTK    
FGFR1TK    
FGFR3TK    
IGF1RTK    
INSRTK    
KITTK    
PDGFRATK    
PDGFRBTK    
SRCTK    
LCKTK    
SYKTK    
ZAP70TK    
TEKTK    
FLT4TK    
KDRTK    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
MAPK14CMGC   
AURKAOther   
PLK1Other   
PLK2Other   
PLK3Other   
ABL1TK   
EGFRTK   
FGFR1TK   
FGFR3TK   
FLT4TK   
IGF1RTK   
INSRTK   
KDRTK   
KITTK   
LCKTK   
PDGFRATK   
PDGFRBTK   
SRCTK   
SYKTK   
TEKTK   
TNK2TK   
ZAP70TK