Kinase profiling results of kinases in KIF 2OFUA_1N9 (LCK, PDB code: 2OFU, chain A)
Template Kinase: LCK
Template inhibitor: 2-aminopyrimidine carbamate, 42

55 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C
CDK5CMGC       
CDC2L5CMGC       
CDKL2CMGC       
MAPK14CMGC       
AURKAOther       
AURKCOther       
PLK2Other       
PLK3Other       
ABL1TK       
ABL2TK       
TNK2TK       
ALKTK       
LTKTK       
CSKTK       
DDR1TK       
DDR2TK       
EGFRTK       
EPHA1TK       
EPHA2TK       
EPHA3TK       
EPHA4TK       
EPHA5TK       
EPHA6TK       
EPHA8TK       
EPHB1TK       
EPHB2TK       
EPHB4TK       
EPHB6TK       
PTK2BTK       
FGFR1TK       
FGFR2TK       
IGF1RTK       
INSRTK       
JAK2TK       
MUSKTK       
CSF1RTK       
KITTK       
PDGFRATK       
PDGFRBTK       
RETTK       
FRKTK       
SRCTK       
YES1TK       
BLKTK       
LCKTK       
LYNTK       
SYKTK       
BTKTK       
NTRK1TK       
NTRK2TK       
NTRK3TK       
BRAFTKL       
RAF1TKL       
ACVR1TKL       

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
PRKCBAGC    
PRKCBAGC    
CDK5CMGC    
MAPK14CMGC    
AURKAOther    
AURKCOther    
PLK2Other    
PLK3Other    
ABL1TK    
ABL2TK    
ALKTK    
BLKTK    
BTKTK    
CSF1RTK    
CSKTK    
DDR2TK    
EGFRTK    
EPHA1TK    
EPHA2TK    
EPHA3TK    
EPHA4TK    
EPHA5TK    
EPHA6TK    
EPHA8TK    
EPHB1TK    
EPHB2TK    
EPHB4TK    
FGFR1TK    
FGFR2TK    
FRKTK    
IGF1RTK    
INSRTK    
JAK2TK    
KITTK    
LCKTK    
LTKTK    
LYNTK    
MUSKTK    
NTRK1TK    
NTRK2TK    
NTRK3TK    
PDGFRATK    
PDGFRBTK    
PTK2BTK    
RETTK    
SRCTK    
SYKTK    
TNK2TK    
YES1TK    
ACVR1TKL    
BRAFTKL    
RAF1TKL