Kinase profiling results of kinases in KIF 3BYMA_AM0 (LCK, PDB code: 3BYM, chain A)
Template Kinase: LCK
Template inhibitor: triazine 34

 39 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
CDK2CMGC   
MAPK14CMGC   
AURKAOther   
NEK2Other   
PLK3Other   
ABL1TK   
TNK2TK   
ALKTK   
CSKTK   
EGFRTK   
ERBB4TK   
EPHB4TK   
FGFR1TK   
FGFR2TK   
IGF1RTK   
INSRTK   
JAK2TK   
KITTK   
RETTK   
FGRTK   
FYNTK   
SRCTK   
YES1TK   
BLKTK   
HCKTK   
LCKTK   
LYNTK   
PTK6TK   
SRMSTK   
SYKTK   
ZAP70TK   
BTKTK   
TECTK   
IRAK4TKL   
BRAFTKL   
RAF1TKL   
TGFBR1TKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
PRKCAAGC     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
MAPK14CMGC     
AURKAOther     
NEK2Other     
PLK3Other     
ABL1TK     
ALKTK     
BLKTK     
BTKTK     
CSKTK     
EGFRTK     
EPHB4TK     
ERBB4TK     
FGFR1TK     
FGFR2TK     
FGRTK     
FYNTK     
HCKTK     
IGF1RTK     
INSRTK     
JAK2TK     
KITTK     
LCKTK     
LYNTK     
PTK6TK     
RETTK     
SRCTK     
SRMSTK     
SYKTK     
TECTK     
TNK2TK     
YES1TK     
ZAP70TK     
BRAFTKL     
IRAK4TKL     
RAF1TKL     
TGFBR1TKL