Kinase profiling results of kinases in KIF 3EOCA_T2A (CDK2, PDB code: 3EOC, chain A)
Template Kinase: CDK2
Template inhibitor: 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine

42 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
PDPK1AGC  
PRKCDAGC  
PRKCQAGC  
RPS6KB1AGC  
CHEK1CAMK  
CHEK2CAMK  
CDK2CMGC  
CDK4CMGC  
CDK5CMGC  
CDK9CMGC  
CSNK2A1CMGC  
CLK4CMGC  
GSK3BCMGC  
MAPK10CMGC  
MAPK8CMGC  
MAPK14CMGC  
AURKAOther  
AURKBOther  
CHUKOther  
PLK1Other  
PLK3Other  
ABL1TK  
TNK2TK  
FGFR1TK  
JAK1TK  
JAK2TK  
JAK3TK  
METTK  
FGRTK  
FYNTK  
SRCTK  
YES1TK  
BLKTK  
HCKTK  
LCKTK  
LYNTK  
PTK6TK  
SRMSTK  
ZAP70TK  
IRAK4TKL  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C
PDPK1AGC      
PRKCAAGC      
PRKCDAGC      
PRKCQAGC      
RPS6KB1AGC      
CHEK1CAMK      
CHEK2CAMK      
CDC2CMGC      
CDC2CMGC      
CDK2CMGC      
CDK4CMGC      
CDK5CMGC      
CDK9CMGC      
CLK4CMGC      
CSNK2A1CMGC      
GSK3BCMGC      
MAPK10CMGC      
MAPK14CMGC      
MAPK8CMGC      
AURKAOther      
AURKBOther      
CHUKOther      
PLK1Other      
PLK3Other      
ABL1TK      
BLKTK      
FGFR1TK      
FGRTK      
FYNTK      
HCKTK      
JAK1TK      
JAK2TK      
JAK3TK      
LCKTK      
LYNTK      
METTK      
PTK6TK      
SRCTK      
SRMSTK      
TNK2TK      
YES1TK      
ZAP70TK      
IRAK4TKL