Kinase profiling results of kinases in KIF 3OT8A_MI5 (CHEK1, PDB code: 3OT8, chain A)
Template Kinase: CHEK1
Template inhibitor: VX_680

 14 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
ROCK2AGC
RPS6KA3AGC
CHEK1CAMK
MAPKAPK23
PIM1CAMK
CDK2CMGC
CSNK2A1CMGC
GSK3BCMGC
MAPK14CMGC
AURKAOther
AURKBOther
PLK3Other
SRCTK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
ROCK2AGC
RPS6KA3AGC
CHEK1CAMK
MAPKAPK2CAMK
PIM1CAMK
CDK2CMGC
CSNK2A1CMGC
GSK3BCMGC
MAPK14CMGC
AURKAOther
AURKBOther
PLK3Other
SRCTK
IRAK4TKL