Kinase profiling results of kinases in KIF 2X2MA_X2M (RET, PDB code: 2X2M, chain A)
Template Kinase: RET
Template inhibitor: Semaxanib

 24 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
RPS6KA6AGC
RPS6KA6CAMK
ALKTK
LTKTK
PTK2TK
FGFR1TK
JAK2TK
JAK3TK
TYK2TK
CSF1RTK
KITTK
PDGFRBTK
RETTK
SRCTK
NTRK1TK
NTRK2TK
NTRK3TK
IRAK4TKL
LRRK2TKL
MAP3K11TKL
MAP3K9TKL
RAF1TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C C C C
PDPK1AGC          
RPS6KA1AGC          
RPS6KA2AGC          
RPS6KA6AGC          
ALKTK          
CSF1RTK          
FGFR1TK          
JAK2TK          
JAK3TK          
KITTK          
LTKTK          
NTRK1TK          
NTRK2TK          
NTRK3TK          
PDGFRBTK          
PTK2TK          
RETTK          
SRCTK          
TYK2TK          
IRAK4TKL          
LRRK2TKL          
MAP3K11TKL          
MAP3K9TKL          
RAF1TKL