Kinase profiling results of kinases in KIF 2ESMA_M77 (ROCK1, PDB code: 2ESM, chain A)
Template Kinase: ROCK1
Template inhibitor: HMS2231N23

 6 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT2AGC
ROCK1AGC
ROCK2AGC
PRKACAAGC
PRKXAGC
PKN2AGC

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
AKT2AGC 
PKN2AGC 
PRKACAAGC 
PRKXAGC 
ROCK1AGC 
ROCK2AGC