Kinase profiling results of kinases in KIF 3NCZA_3NC (ROCK1, PDB code: 3NCZ, chain A)
Template Kinase: ROCK1
Template inhibitor: Cis-4-Amino-N-(7-Chloro-1-Oxo-1,2-Dihydroisoquinolin-6-Yl)cyclohexanecarboxamide

 4 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
ROCK1AGC
ROCK2AGC
PRKG2AGC
PKN2AGC

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PKN2AGC
PRKG2AGC
ROCK1AGC
ROCK2AGC