Kinase profiling results of kinases in KIF 2Z7QA_ABG (RPS6KA1, PDB code: 2Z7Q, chain A)
Template Kinase: RPS6KA1
Template inhibitor: adenosine tetraphosphate

 20 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
PRKCIAGC
RPS6KA1AGC
RPS6KA1CAMK
MAPKAPK23
PIM1CAMK
CHEK2CAMK
CDK2CMGC
CDK9CMGC
GSK3BCMGC
NEK2Other
TTKOther
ABL1TK
ALKTK
EGFRTK
IGF1RTK
INSRTK
RETTK
SRCTK
HCKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
PRKCIAGC
RPS6KA1AGC
SGK1AGC
CHEK2CAMK
MAPKAPK2CAMK
PIM1CAMK
CDK2CMGC
CDK9CMGC
GSK3BCMGC
NEK2Other
TTKOther
ABL1TK
ALKTK
EGFRTK
HCKTK
IGF1RTK
INSRTK
RETTK
SRCTK