Kinase profiling results of kinases in KIF 2Z7SA_P01 (RPS6KA1, PDB code: 2Z7S, chain A)
Template Kinase: RPS6KA1
Template inhibitor: Lopac0_000938

 32 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
RPS6KA6AGC
RPS6KA6CAMK
CHEK1CAMK
PIM1CAMK
PIM3CAMK
CDK2CMGC
CDK3CMGC
CDK5CMGC
CDK9CMGC
GSK3BCMGC
MAPK1CMGC
MAPK14CMGC
TTKOther
SLKSTE
ABL1TK
ALKTK
EGFRTK
INSRTK
MUSKTK
SRCTK
YES1TK
HCKTK
BTKTK
TXKTK
NTRK1TK
NTRK2TK
NTRK3TK
MAP3K11TKL
MAP3K9TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
RPS6KA1AGC       
RPS6KA2AGC       
RPS6KA6AGC       
CHEK1CAMK       
PIM1CAMK       
PIM3CAMK       
CDC2CMGC       
CDC2CMGC       
CDK2CMGC       
CDK3CMGC       
CDK5CMGC       
CDK6CMGC       
CDK6CMGC       
CDK9CMGC       
GSK3BCMGC       
MAPK1CMGC       
MAPK14CMGC       
TTKOther       
SLKSTE       
ABL1TK       
ALKTK       
BTKTK       
EGFRTK       
HCKTK       
INSRTK       
MUSKTK       
NTRK1TK       
NTRK2TK       
NTRK3TK       
SRCTK       
TXKTK       
YES1TK       
MAP3K11TKL       
MAP3K9TKL