Kinase profiling results of kinases in KIF 2WU6A_DKI (CLK3, PDB code: 2WU6, chain A)
Template Kinase: CLK3
Template inhibitor: 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

 26 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CAMK2ACAMK
CAMK2DCAMK
STK33CAMK
DAPK3CAMK
CHEK2CAMK
CDK2CMGC
CDK3CMGC
CDK5CMGC
CDK9CMGC
CSNK2A2CMGC
CLK1CMGC
CLK2CMGC
CLK3CMGC
CLK4CMGC
DYRK1ACMGC
DYRK1BCMGC
GSK3ACMGC
GSK3BCMGC
MAPK10CMGC
MAPK8CMGC
NLKCMGC
SRPK1CMGC
SRPK2CMGC
SRPK3CMGC

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
CAMK2ACAMK  
CAMK2DCAMK  
CHEK2CAMK  
DAPK3CAMK  
STK33CAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK3CMGC  
CDK5CMGC  
CDK6CMGC  
CDK6CMGC  
CDK9CMGC  
CLK1CMGC  
CLK2CMGC  
CLK3CMGC  
CLK4CMGC  
CSNK2A2CMGC  
DYRK1ACMGC  
DYRK1BCMGC  
GSK3ACMGC  
GSK3BCMGC  
MAPK10CMGC  
MAPK8CMGC  
NLKCMGC  
SRPK1CMGC  
SRPK2CMGC  
SRPK3CMGC