Kinase profiling results of kinases in KIF 2WTWA_ZZL (AURKA, PDB code: 2WTW, chain A)
Template Kinase: AURKA
Template inhibitor: MLN8054

 35 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
SIK1CAMK   
DAPK2CAMK   
STK17ACAMK   
STK17BCAMK   
MAPKAPK53   
CDK2CMGC   
CDK4CMGC   
MAPK10CMGC   
MAPK8CMGC   
AURKAOther   
AURKBOther   
AURKCOther   
PLK4Other   
STK10STE   
ABL1TK   
ABL2TK   
TNK1TK   
ALKTK   
CSKTK   
EGFRTK   
EPHA3TK   
EPHB1TK   
PTK2BTK   
FERTK   
FGFR1TK   
FGFR2TK   
FGFR3TK   
BLKTK   
LCKTK   
BMXTK   
BTKTK   
TECTK   
TEKTK   
TIE1TK   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
DAPK2CAMK   
MAPKAPK5CAMK   
STK17ACAMK   
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
CDK4CMGC   
MAPK10CMGC   
MAPK8CMGC   
AURKAOther   
AURKBOther   
AURKCOther   
STK10STE   
ABL1TK   
ABL2TK   
ALKTK   
BLKTK   
BMXTK   
BTKTK   
CSKTK   
EGFRTK   
EPHA3TK   
EPHB1TK   
FERTK   
FGFR1TK   
FGFR2TK   
FGFR3TK   
LCKTK   
PTK2BTK   
TECTK   
TEKTK