Kinase profiling results of kinases in KIF 2WOTA_ZZG (TGFBR1, PDB code: 2WOT, chain A)
Template Kinase: TGFBR1
Template inhibitor: 4-pyridinoxy-2-anilinopyridine-based compound, 1

10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
ABL1TK  
CSKTK  
EPHB4TK  
FGRTK  
FYNTK  
SRCTK  
LCKTK  
BRAFTKL  
RAF1TKL  
TGFBR1TKL  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
ABL1TK     
CSKTK     
EPHB4TK     
FGRTK     
FYNTK     
LCKTK     
SRCTK     
BRAFTKL     
RAF1TKL     
TGFBR1TKL