Kinase profiling results of kinases in KIF 1U54A_ACP (TNK2, PDB code: 1U54, chain A)
Template Kinase: TNK2
Template inhibitor: adenosine tetraphosphate

 20 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CDK2CMGC
AURKAOther
STK24STE
ABL1TK
TNK2TK
ALKTK
EGFRTK
ERBB3TK
EPHA3TK
FGFR1TK
FGFR2TK
INSRTK
METTK
KITTK
RETTK
SRCTK
HCKTK
LCKTK
ZAP70TK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CDK2CMGC
AURKAOther
STK24STE
ABL1TK
ALKTK
EGFRTK
EPHA3TK
FGFR1TK
FGFR2TK
HCKTK
INSRTK
KITTK
LCKTK
METTK
RETTK
SRCTK
TNK2TK
ZAP70TK
IRAK4TKL