Kinase profiling results of kinases in KIF 3NZ0A_IZA (TYK2, PDB code: 3NZ0, chain A)
Template Kinase: TYK2
Template inhibitor: Pyridone 6

12 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
TNK2TK
ALKTK
LTKTK
FERTK
TYK2TK
RETTK
ROS1TK
FYNTK
HCKTK
NTRK1TK
NTRK2TK
NTRK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
ALKTK    
FERTK    
FYNTK    
HCKTK    
LTKTK    
NTRK1TK    
NTRK2TK    
NTRK3TK    
RETTK    
ROS1TK    
TNK2TK    
TYK2TK