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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
2 MUSK related diseases
H00770
Congenital myasthenic syndrome
608931
Myasthenic syndrome, congenital, associated with acetylcholine receptor deficiency
Summary of query kinase
Query kinase
MUSK (
O15146
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
72 (
Total 57 inhibitors
)
Number of MUSK related diseases
2 (
H00770
608931
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
31
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
1AQ1A_STU
(CDK2)
TK
staurosporine
I
195
76
118
195
76
118
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
2XIKA_J60
(STK25)
TK
SU11652
I
59
49
65
59
49
65
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
1PKDA_UCN
(CDK2)
TK
UCN 02
I
195
67
118
195
67
118
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
2VTTA_LZD
(CDK2)
TK
pyrazole dia...
I
158
42
111
158
42
111
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
2WIHA_P48
(CDK2)
TK
VX_680
I
111
425
105
111
425
105
A
1R78A_FMD
(CDK2)
TK
4-alkynyl ox...
I
127
24
97
127
24
97
A
2J51A_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
2JFLA_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
2Z7SA_P01
(RPS6KA1)
TK
Lopac0_000938
I
32
214
49
32
214
49
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
3BPRA_OLP
(MERTK)
TK
compound 52
I
9
10
19
9
10
19
A
3EIDA_PO5
(CDK2)
TK
AC1O6YZF
I
63
211
77
63
211
77
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
3DOGA_NNN
(CDK2)
TK
NSC743927
I
50
239
48
50
239
48
B
26
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
2WKMA_PFY
(MET)
TK
PHA-665752
I
38
34
98
38
34
98
B
2A0CX_CK9
(CDK2)
TK
purine deriv...
I
45
226
50
45
226
50
B
3PJ8A_404
(CDK2)
TK
imidazo[2,1-...
I
47
223
49
47
223
49
B
2XA4A_AZ5
(JAK2)
TK
AZD1480, AZ...
I
15
85
58
15
85
58
B
2A4LA_RRC
(CDK2)
TK
roscovitine
I
50
240
50
50
240
50
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
2F2CB_AP9
(CDK6)
TK
MLS000911551
I
24
147
39
24
147
39
B
1OIRA_HDY
(CDK2)
TK
AC1O6YZF
I
51
203
64
51
203
64
B
1CKPA_PVB
(CDK2)
TK
Purvalanol B
I
35
76
36
35
76
36
B
1UNLA_RRC
(CDK5)
TK
roscovitine
I
45
237
47
45
237
47
B
3DDQA_RRC
(CDK2)
TK
roscovitine
I
50
240
50
50
240
50
B
1W0XC_OLO
(CDK2)
TK
olomoucine
I
43
195
47
43
195
47
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
B
1YOMA_P01
(SRC)
TK
Lopac0_000938
I
27
95
57
27
95
57
B
3NS9A_NS9
(CDK2)
TK
pyrazolo[1,5...
I
44
196
47
44
196
47
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
D
2
1R0PA_KSA
(MET)
TK
k-252a
I
28
79
64
D
1R0PA_KSA
(MET)
TK
k-252a
I
28
79
64
28
79
64
D
2WGJA_VGH
(MET)
TK
Crizotinib
I
21
23
55
21
23
55
E
13
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
E
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
3G0FA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
1YWNA_LIF
(KDR)
TK
AC1NS1DP
II
17
49
42
17
49
42
E
2OFVA_242
(LCK)
TK
2ofv
II
28
181
65
28
181
65
E
3Q96A_0NF
(BRAF)
TK
(2s)-N-[3-(2...
II
19
21
35
19
21
35
E
3QRIA_919
(ABL1)
TK
Sorafenib
II
23
18
54
23
18
54
E
3QRJA_919
(ABL1)
TK
Sorafenib
II
23
18
54
23
18
54
E
2OG8A_1N8
(LCK)
TK
1N8
II
35
190
69
35
190
69
E
1UWHA_BAX
(BRAF)
TK
Sorafenib
II
19
39
35
19
39
35
E
1UWJA_BAX
(BRAF)
TK
Sorafenib
II
19
39
35
19
39
35
E
3LQ8A_88Z
(MET)
TK
AZD_1152HQPA
II
19
71
36
19
71
36
E
3C7QA_XIN
(KDR)
TK
BIBF1120
I
25
56
50
25
56
50
E
3C1XA_CKK
(MET)
TK
AZD_1152HQPA
II
19
77
36
19
77
36