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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
5 PDGFRA related diseases
H00042
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
606764
Gastrointestinal stromal tumor, somatic
607685
Hypereosinophilic syndrome, idiopathic, resistant to imatinib
Summary of query kinase
Query kinase
PDGFRA (
P16234
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
84 (
Total 297 inhibitors
)
Number of PDGFRA related diseases
5 (
H00042
hsa05215
hsa05218
606764
607685
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
45
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
1XBBA_STI
(SYK)
TK
Imatinib
I
31
170
75
31
170
75
A
1Y57A_MPZ
(SRC)
TK
MPZ
I
42
155
94
42
155
94
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
3A4OX_STU
(LYN)
TK
staurosporine
I
73
70
88
73
70
88
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
83
291
121
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
2GQGA_1N1
(ABL1)
TK
Dasatinib
I
74
32
117
74
32
117
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
1M17A_AQ4
(EGFR)
TK
Erlotinib
I
43
166
82
43
166
82
A
3GQLA_GQL
(FGFR1)
TK
HMS3401N17
I
14
14
58
14
14
58
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
2HK5A_1BM
(HCK)
TK
1BM
I
24
121
70
24
121
70
A
2BDJA_HET
(SRC)
TK
AP-23464
I
8
26
23
8
26
23
A
3B2WA_9NH
(LCK)
TK
MLS000911569
II
30
32
98
30
32
98
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
3KMMA_LHL
(LCK)
TK
AZD_1152HQPA
I
29
99
95
29
99
95
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
3PJ1A_LHL
(BTK)
TK
AZD_1152HQPA
I
30
99
96
30
99
96
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
2FGIA_PD1
(FGFR1)
TK
Pyrido[2,3-d...
I
24
157
70
24
157
70
A
3KXZA_925
(LCK)
TK
2e9n
I
12
18
45
12
18
45
A
2ITTA_AEE
(EGFR)
TK
GNF-Pf-5343
I
26
170
77
26
170
77
A
3BEAA_IXH
(CSF1R)
TK
Pyrido[2,3-d...
I
19
77
69
19
77
69
A
2JIUA_AEE
(EGFR)
TK
GNF-Pf-5343
I
26
170
77
26
170
77
A
3OCSA_746
(BTK)
TK
CGI1746, 2
I
25
89
76
25
89
76
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3BYOA_AM9
(LCK)
TK
AC1NS8OV
I
28
144
90
28
144
90
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
B
5
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
E
32
3C7QA_XIN
(KDR)
TK
BIBF1120
I
25
56
50
E
3C7QA_XIN
(KDR)
TK
BIBF1120
I
25
56
50
25
56
50
E
3B8QA_900
(KDR)
TK
3b8q
II
6
79
20
6
79
20
E
3KRLA_KRL
(CSF1R)
TK
5-Cyano-N-[4...
I
11
88
23
11
88
23
E
2OH4A_GIG
(KDR)
TK
2oh4
II
9
89
35
9
89
35
E
1T46A_STI
(KIT)
TK
Imatinib
II
22
176
56
22
176
56
E
3GVUA_STI
(ABL2)
TK
Imatinib
II
12
177
42
12
177
42
E
2HYYA_STI
(ABL1)
TK
Imatinib
II
16
182
52
16
182
52
E
2E2BA_406
(ABL1)
TK
Bafetinib
II
18
200
48
18
200
48
E
2OO8X_RAJ
(TEK)
TK
RAJ
II
16
246
36
16
246
36
E
3BE2A_RAJ
(KDR)
TK
RAJ
II
19
249
47
19
249
47
E
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
3G0FA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
2OSCA_MUH
(TEK)
TK
2osc
II
17
136
36
17
136
36
E
3CPBA_C92
(KDR)
TK
3cpb
II
12
86
32
12
86
32
E
3QRIA_919
(ABL1)
TK
Sorafenib
II
23
18
54
23
18
54
E
3QRJA_919
(ABL1)
TK
Sorafenib
II
23
18
54
23
18
54
E
2OFVA_242
(LCK)
TK
2ofv
II
28
181
65
28
181
65
E
1YWNA_LIF
(KDR)
TK
AC1NS1DP
II
17
49
42
17
49
42
E
2OG8A_1N8
(LCK)
TK
1N8
II
35
190
69
35
190
69
E
3HNGA_8ST
(FLT1)
TK
HMS3229O07
II
10
91
21
10
91
21
E
2P2IA_608
(KDR)
TK
nicotinamide...
II
15
58
45
15
58
45
E
3CS9A_NIL
(ABL1)
TK
Nilotinib
II
19
132
48
19
132
48
E
3EFLA_706
(KDR)
TK
Motesanib
II
15
69
43
15
69
43
E
3EWHA_K11
(KDR)
TK
k11
II
17
27
46
17
27
46
E
3DKOA_IHZ
(EPHA7)
TK
DB07970
II
7
11
15
7
11
15
E
3CPCA_C52
(KDR)
TK
3cpc
II
5
10
16
5
10
16
E
3ETAA_351
(INSR)
TK
CP_724714
II
6
13
16
6
13
16
E
3DTWA_A96
(KDR)
TK
DB07326
II
8
35
25
8
35
25
E
3KRJA_KRJ
(CSF1R)
TK
AMG_706
I
11
49
23
11
49
23
E
3BYSA_AM5
(LCK)
TK
Aminopyrimid...
II
20
220
65
20
220
65
E
2HIWA_7MP
(ABL1)
TK
2hiw
II
16
47
53
16
47
53
E
3BYUA_AM6
(LCK)
TK
Aminopyrimid...
II
19
186
61
19
186
61
F
2
2RL5A_2RL
(KDR)
TK
Sorafenib
II
12
94
45
F
2RL5A_2RL
(KDR)
TK
Sorafenib
II
12
94
45
12
94
45
F
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
12
142
33