Summary of query kinase
Query kinase RPS6KA1 (Q15418)
Kinase group AGC
Number of inhibitors 106
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 RPS6KA1 oxadiazole-containing compound, 12c BD00025004 n/a 1 n/a n/a n/a BindingDB BindingDB
1 RPS6KA1 CHEMBL1271533 BD50329882 n/a 1100 n/a n/a n/a BindingDB BindingDB
2 RPS6KA1 oxadiazole-containing compound, 12b BD00025003 n/a 1259 n/a n/a n/a BindingDB BindingDB
3 RPS6KA1 oxadiazole-containing compound, 11a BD00024998 n/a 13 n/a n/a n/a BindingDB BindingDB
4 RPS6KA1 CHEMBL392167 BD50207806 n/a 1900 n/a n/a n/a BindingDB BindingDB
5 RPS6KA1 CHEMBL478629 BD50262685 n/a 210 n/a n/a n/a BindingDB BindingDB
6 RPS6KA1 CHEMBL1271480 BD50329879 n/a 2100 n/a n/a n/a BindingDB BindingDB
7 RPS6KA1 pyrazolo[1,5-a]pyrimidine 4h BD00005416 n/a 2100 n/a n/a n/a BindingDB BindingDB
8 RPS6KA1 CHEMBL1271532 BD50329881 n/a 220 n/a n/a n/a BindingDB BindingDB
9 RPS6KA1 oxadiazole-containing compound, 12a BD00025002 n/a 251 n/a n/a n/a BindingDB BindingDB
10 RPS6KA1 oxadiazole-containing compound, 13 BD00025006 n/a 251 n/a n/a n/a BindingDB BindingDB
11 RPS6KA1 CHEMBL511410 BD50259563 n/a 290 n/a n/a n/a BindingDB BindingDB
12 RPS6KA1 CHEMBL1271642 BD50329886 n/a 3400 n/a n/a n/a BindingDB BindingDB
13 RPS6KA1 oxadiazole-containing compound, 10 BD00024997 n/a 44 n/a n/a n/a BindingDB BindingDB
14 RPS6KA1 CHEMBL1092754 BD50314344 n/a 45.9 n/a n/a n/a BindingDB BindingDB
15 RPS6KA1 CHEMBL1271641 BD50329885 n/a 560 n/a n/a n/a BindingDB BindingDB
16 RPS6KA1 oxadiazole-containing compound, 12d BD00025005 n/a 6 n/a n/a n/a BindingDB BindingDB
17 RPS6KA1 oxadiazole-containing compound, 11b BD00024999 n/a 71 n/a n/a n/a BindingDB BindingDB
18 RPS6KA1 CHEMBL467079 BD50259532 n/a 780 n/a n/a n/a BindingDB BindingDB
19 RPS6KA1 CHEMBL466496 BD50259376 n/a 810 n/a n/a n/a BindingDB BindingDB
20 RPS6KA1 CHEMBL1087650 BD50311985 n/a 9710 n/a n/a n/a BindingDB BindingDB
21 RPS6KA1 CHEMBL162 BD50059889 n/a <0.1 43 n/a n/a BindingDB BindingDB
22 RPS6KA1 INCB18424 INCB18424 n/a n/a 120 n/a n/a NB2011DRx NB2011DRx
23 RPS6KA1 TG_101348 TG_101348 n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
24 RPS6KA1 CHEMBL440084 BD50110208 1300000 n/a 1300 n/a n/a BindingDB BindingDB
25 RPS6KA1 SB_431542 SB_431542 n/a n/a 1300 n/a n/a NB2008 NB2008
26 RPS6KA1 Sunitinib Sunitinib n/a n/a 140 n/a n/a NB2008 NB2008
27 RPS6KA1 Sunitinib Sunitinib n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
28 RPS6KA1 CP_690550 CP_690550 n/a n/a 1400 n/a n/a NB2011DRx NB2011DRx
29 RPS6KA1 TAE_684 TAE_684 n/a n/a 160 n/a n/a NB2011DRx NB2011DRx
30 RPS6KA1 LY_317615 LY_317615 n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
31 RPS6KA1 SB-202190 BD50104383 n/a n/a 170 n/a n/a BindingDB BindingDB
32 RPS6KA1 SB_202190 SB_202190 n/a n/a 170 n/a n/a NB2008 NB2008
33 RPS6KA1 cid_10138259 BD00031095 180000 n/a 180 n/a n/a BindingDB BindingDB
34 RPS6KA1 BIBF_1120der BIBF_1120der n/a n/a 180 n/a n/a NB2011DRx NB2011DRx
35 RPS6KA1 SU_14813 SU_14813 n/a n/a 180 n/a n/a NB2008 NB2008
36 RPS6KA1 SU_14813 SU_14813 n/a n/a 180 n/a n/a NB2011DRx NB2011DRx
37 RPS6KA1 JNJ_28312141 JNJ_28312141 n/a n/a 2100 n/a n/a NB2011DRx NB2011DRx
38 RPS6KA1 PP_242 PP_242 n/a n/a 2100 n/a n/a NB2011DRx NB2011DRx
39 RPS6KA1 TG_100_115 TG_100_115 n/a n/a 220 n/a n/a NB2011DRx NB2011DRx
40 RPS6KA1 Flavopiridol Flavopiridol n/a n/a 2300 n/a n/a NB2008 NB2008
41 RPS6KA1 Flavopiridol Flavopiridol n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
42 RPS6KA1 CHEMBL608533 BD50326053 n/a n/a 260 n/a n/a BindingDB BindingDB
43 RPS6KA1 CEP_701 CEP_701 n/a n/a 28 n/a n/a NB2011DRx NB2011DRx
44 RPS6KA1 CHEBI:668344 BD50298226 n/a n/a 320 n/a n/a BindingDB BindingDB
45 RPS6KA1 SB_203580 SB_203580 n/a n/a 320 n/a n/a NB2008 NB2008
46 RPS6KA1 SB_203580 SB_203580 n/a n/a 320 n/a n/a NB2011DRx NB2011DRx
47 RPS6KA1 BMS_345541 BMS_345541 n/a n/a 3300 n/a n/a NB2011DRx NB2011DRx
48 RPS6KA1 KW_2449 KW_2449 n/a n/a 3400 n/a n/a NB2011DRx NB2011DRx
49 RPS6KA1 LY333531 BD00017055 n/a n/a 400 n/a n/a BindingDB BindingDB
50 RPS6KA1 ZD6474 BD00004655 n/a n/a 400 n/a n/a BindingDB BindingDB
51 RPS6KA1 LY_333531 LY_333531 n/a n/a 400 n/a n/a NB2008 NB2008
52 RPS6KA1 LY_333531 LY_333531 n/a n/a 400 n/a n/a NB2011DRx NB2011DRx
53 RPS6KA1 Vandetanib Vandetanib n/a n/a 400 n/a n/a NB2011DRx NB2011DRx
54 RPS6KA1 ZD_6474 ZD_6474 n/a n/a 400 n/a n/a NB2008 NB2008
55 RPS6KA1 JNJ-7706621 BD00006866 n/a n/a 4000 n/a n/a BindingDB BindingDB
56 RPS6KA1 JNJ_7706621 JNJ_7706621 n/a n/a 4000 n/a n/a NB2008 NB2008
57 RPS6KA1 GSK_1838705A GSK_1838705A n/a n/a 410 n/a n/a NB2011DRx NB2011DRx
58 RPS6KA1 Staurosporine Staurosporine n/a n/a 43 n/a n/a NB2008 NB2008
59 RPS6KA1 Staurosporine Staurosporine n/a n/a 43 n/a n/a NB2011DRx NB2011DRx
60 RPS6KA1 CHEMBL522892 BD50265677 n/a n/a 450 n/a n/a BindingDB BindingDB
61 RPS6KA1 CHIR_258 CHIR_258 n/a n/a 450 n/a n/a NB2008 NB2008
62 RPS6KA1 CHIR_258 CHIR_258 n/a n/a 450 n/a n/a NB2011DRx NB2011DRx
63 RPS6KA1 MLN_8054 MLN_8054 n/a n/a 4800 n/a n/a NB2011DRx NB2011DRx
64 RPS6KA1 R406 R406 n/a n/a 490 n/a n/a NB2011DRx NB2011DRx
65 RPS6KA1 BI_2536 BI_2536 n/a n/a 5400 n/a n/a NB2011DRx NB2011DRx
66 RPS6KA1 CHEMBL603469 BD50308060 n/a n/a 62 n/a n/a BindingDB BindingDB
67 RPS6KA1 CI-1033 BD00004779 6200000 n/a 6200 n/a n/a BindingDB BindingDB
68 RPS6KA1 CI_1033 CI_1033 n/a n/a 6200 n/a n/a NB2008 NB2008
69 RPS6KA1 CI_1033 CI_1033 n/a n/a 6200 n/a n/a NB2011DRx NB2011DRx
70 RPS6KA1 CHEBI:668343 BD50298227 n/a n/a 690 n/a n/a BindingDB BindingDB
71 RPS6KA1 PKC_412 PKC_412 n/a n/a 690 n/a n/a NB2008 NB2008
72 RPS6KA1 PKC_412 PKC_412 n/a n/a 690 n/a n/a NB2011DRx NB2011DRx
73 RPS6KA1 FLAVOPIRIDOL BD50088605 n/a n/a 720 n/a n/a BindingDB BindingDB
74 RPS6KA1 HKI_272 HKI_272 n/a n/a 7400 n/a n/a NB2011DRx NB2011DRx
75 RPS6KA1 VX_680 VX_680 n/a n/a 7900 n/a n/a NB2011DRx NB2011DRx
76 RPS6KA1 SU11248 BD00004814 140000 n/a 96 n/a n/a BindingDB BindingDB
77 RPS6KA1 ABG ABG n/a n/a n/a n/a n/a PDB PDB
78 RPS6KA1 CAS120685_11_2 CAS120685_11_2 n/a n/a n/a n/a 0.43 NB2011RBC NB2011RBC
79 RPS6KA1 CAS133052_90_1 CAS133052_90_1 n/a n/a n/a n/a 4.67 NB2011RBC NB2011RBC
80 RPS6KA1 CAS133053_19_7 CAS133053_19_7 n/a n/a n/a n/a 15.99 NB2011RBC NB2011RBC
81 RPS6KA1 CAS135897_06_2 CAS135897_06_2 n/a n/a n/a n/a 1.58 NB2011RBC NB2011RBC
82 RPS6KA1 CAS136194_77_9 CAS136194_77_9 n/a n/a n/a n/a 9.7 NB2011RBC NB2011RBC
83 RPS6KA1 CAS151342_35_7 CAS151342_35_7 n/a n/a n/a n/a 5.9 NB2011RBC NB2011RBC
84 RPS6KA1 CAS160807_49_8 CAS160807_49_8 n/a n/a n/a n/a 39.63 NB2011RBC NB2011RBC
85 RPS6KA1 CAS204005_46_9 CAS204005_46_9 n/a n/a n/a n/a 44.05 NB2011RBC NB2011RBC
86 RPS6KA1 CAS220792_57_4 CAS220792_57_4 n/a n/a n/a n/a 37.21 NB2011RBC NB2011RBC
87 RPS6KA1 CAS244148_46_7 CAS244148_46_7 n/a n/a n/a n/a 31.08 NB2011RBC NB2011RBC
88 RPS6KA1 CAS257879_35_9 CAS257879_35_9 n/a n/a n/a n/a 7.54 NB2011RBC NB2011RBC
89 RPS6KA1 CAS326914_10_7 CAS326914_10_7 n/a n/a n/a n/a 13.06 NB2011RBC NB2011RBC
90 RPS6KA1 CAS405169_16_6 CAS405169_16_6 n/a n/a n/a n/a 22.25 NB2011RBC NB2011RBC
91 RPS6KA1 CAS443797_96_4 CAS443797_96_4 n/a n/a n/a n/a 42.12 NB2011RBC NB2011RBC
92 RPS6KA1 CAS443798_55_8 CAS443798_55_8 n/a n/a n/a n/a 5.34 NB2011RBC NB2011RBC
93 RPS6KA1 CAS457081_03_7 CAS457081_03_7 n/a n/a n/a n/a 38.57 NB2011RBC NB2011RBC
94 RPS6KA1 CAS557795_19_4 CAS557795_19_4 n/a n/a n/a n/a 28.05 NB2011RBC NB2011RBC
95 RPS6KA1 CAS608512_97_6 CAS608512_97_6 n/a n/a n/a n/a 20.44 NB2011RBC NB2011RBC
96 RPS6KA1 CAS622387_85_3 CAS622387_85_3 n/a n/a n/a n/a 12.72 NB2011RBC NB2011RBC
97 RPS6KA1 CAS62996_74_1 CAS62996_74_1 n/a n/a n/a n/a 3.52 NB2011RBC NB2011RBC
98 RPS6KA1 CAS667463_62_9 CAS667463_62_9 n/a n/a n/a n/a 47.15 NB2011RBC NB2011RBC
99 RPS6KA1 CAS852547_30_9 CAS852547_30_9 n/a n/a n/a n/a 48.42 NB2011RBC NB2011RBC
100 RPS6KA1 CAS854171_35_0 CAS854171_35_0 n/a n/a n/a n/a 8.85 NB2011RBC NB2011RBC
101 RPS6KA1 CAS856436_16_3 CAS856436_16_3 n/a n/a n/a n/a 0.91 NB2011RBC NB2011RBC
102 RPS6KA1 CAS896138_40_2 CAS896138_40_2 n/a n/a n/a n/a 30.07 NB2011RBC NB2011RBC
103 RPS6KA1 CAS97161_97_2 CAS97161_97_2 n/a n/a n/a n/a -5.99 NB2011RBC NB2011RBC
104 RPS6KA1 P01 P01 n/a n/a n/a n/a n/a PDB PDB
105 RPS6KA1 STU STU n/a n/a n/a n/a n/a PDB PDB