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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AAK1 203
Other AURKA 133
CMGC CDK4 6
CMGC CDK6 13
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
STE MAP3K5 677
CMGC MAPK8 26
CAMK MAPKAPK2 64
CAMK MAPKAPK3 44
Other NEK2 8
CAMK PIM1 38
Other PLK1 53
AGC PRKCA 339
AGC PRKCZ 252
CAMK PRKD1 583
--V-TVDEVLAEGGFAIVFLVRTSNGM--KCALKRMFVNN-EHD---LQVCK--R------EIQIMRDLSG---HKN--IVGYIDSSINNVSSGDVWEVLILMDFCRGG-QVVNLMNQ--RLQTGF--TENEVLQIFCDTCEAVARLHQCK---TPIIHRDLKVENILLH-DRGHY---VLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES----------------QVAICDGNFTIPD-----NSRYS-----------------------------------QDMHCLIRYMLEPDPDKRPD------IYQV------SYFSF---------
---FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKA---GVEHQLRR------EVEIQSHL-R---HPN--ILRLYGYFHD------ATRVYLILEYAPLG-TVYRELQ----KLSKF--DEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL---KIADFGWSV----------HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN--------------TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI--------------
--Y-EPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPN-GGGGGGGLPISTVR------EVALLRRL-EAFEHPN--VVRLMDVCATSR-TDREIKVTLVFEHVDQ--DLRTYLDK--APPPGL--PAETIKDLMRQFLRGLDFLHAN-----CIVHRDLKPENILVT-SGGTV---KLADFGLARI---------YSYQMALTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGN-----------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS------AFRALQHSYL--------------
---YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQT-GEE---GMPLSTIR------EVAVLRHL-ETFEHPN--VVRLFDVCTVSR-TDRETKLTLVFEHVDQ--DLTTYLDK--VPEPGV--PTETIKDMMFQLLRGLDFLHSH-----RVVHRDLKPQNILVT-SSGQI---KLADFGLARI---------YSFQMALTSVVVTLWYRAPEVLL---QSSYATPVDLWSVGCIFAEMFRRKPLFRGS-----------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS------AYSALSHPYF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEE-AVAVKIVDMKR-AVD---CPENI-KK------EICINKML-N---HEN--VVKFYGHRRE------GNIQYLFLEYCSGG-ELFDRIE----PDIGM--PEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL---KISDFGLATVFR------YNNRERLLNKMCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLAGELPWDQP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT------IPDIKKDRW-Y-------------
-YI--MSKTLGSGACGEVKLAFERKTCK-KVAIKIISKRK-FAI---GSAREADPALNVETEIEILKKL-N---HPC--IIKIKNFF-D------AEDYYIVLELMEGG-ELFDKVV----GNKRL--KEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI---------LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH-------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL--------------
--W-EMRERLGTGGFGNVCLYQHRELDL-KIAIKSCRLEL-STK---NRER-WCH------EIQIMKKL-N---HAN--VVKACDVPEELN-ILIHDVPLLAMEYCSGG-DLRKLLNK-PENCCGL--KESQILSLLSDIGSGIRYLHEN-----KIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD---------VDQGSLCTSFVGTLQYLAPELFE---NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG-----------------GPVDLTLKQ-----
DRV-----VLGKGTYGIVYAGRDLSNQV-RIAIKEIPERD-SRY---SQPLH--E------EIALHKHL-K---HKN--IVQYLGSFSE------NGFIKIFMEQVPGG-SLSALLR---SKWGPLKDNEQTIGFYTKQILEGLKYLHDN-----QIVHRDIKGDNVLINTYSGVL---KISDFGTSKRL--------AGINPCTETFTGTLQYMAPEIID-KGPRGYGKAADIWSLGCTIIEMATGKPPFYEL-------------GEPQAAMFKVGMFKVHPEIPESMS-------------------------------------AEAKAFILKCFEPDPDKRAC------ANDLLVDEF-L-------------
---YQNLKPIGSGAQGIVCAAYDAILER-NVAIKKLSRPF-QNQ---THAKRAYR------ELVLMKCV-N---HKN--IIGLLNVFTPQKSLEEFQDVYIVMELMDA--NLCQVIQ------MEL--DHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL---KILDFGLART---------AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVCHKILFPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS------VDEALQHPYI--------------
KVT---SQVLGLGINGKVLQIFNKRTQE-KFALKMLQDCP-KAR----------R------EVELHWRASQ---CPH--IVRIVDVYENLY--AGRKCLLIVMECLDGG-ELFSRIQD--RGDQAF--TEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---------TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSN----------HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI--------------
QLS---KQVLGLGVNGKVLECFHRRTGQ-KCALKLLYDSP-KAR---Q-------------EVDHHWQASG---GPH--IVCILDVYENMH--HGKRCLLIIMECMEGG-ELFSRIQE--RGDQAF--TEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYT-SKEKDAVLKLTDFGFAK----------ETTQNALQTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGFPPFYSN----------TGQAISPGMKRRIRLGQYGFPNPEWSEVS-----------------------------------EDAKQLIRLLLKTDPTERLT------ITQFMNHPWI--------------
---YEVLYTIGTGSYGRCQKIRRKSDGK-ILVWKELDYGS-MTE---AEKQMLVS------EVNLLREL-K---HPN--IVRYYDRIIDR----TNTTLYIVMEYCEGG-DLASVITKGTKERQYL--DEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV---KLGDFGLARIL--------NHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALMPPFTAF--------------SQKELAGKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I-------------
---YQVGPLLGSGGFGSVYSGIRVSDNL-PVAIKHVEKDR-ISD---WGELPNGTRV--PMEVVLLKKV-S---SGFSGVIRLLDWFER------PDSFVLILERPEPVQDLFDFIT----ERGAL--QEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL---KLIDFGSGA----------LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--------------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM--------------
-YV--RGRFLGKGGFAKCFEISDADTKE-VFAGKIVPKSL-LLK---PHQREKMS-----MEISIHRSL-A---HQH--VVGFHGFFED------NDFVFVVLELCRRR-SLLELHK----RRKAL--TEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV--------EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLVGKPPFETS--------------CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRKGTEE-LYAIKILKKDV-VIQ---DDDVECTM-----VEKRVLALLDK---PPF--LTQLHSCFQT------VDRLYFVMEYVNGG-DLMYHIQ----QVGKF--KEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH--------MMDGVTTRTFCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLAGQPPFDGE--------------DEDELFQSIMEHNVSYPKSLS---------------------------------------KEAVSVCKGLMTKHPAKRLG------C---------GPEGERDVREHAFF
--F-DLIRVIGRGSYAKVLLVRLKKNDQ-IYAMKVVKKEL-VHD---DEDIDWVQ-----TEKHVFEQASS---NPF--LVGLHSCFQT------TSRLFLVIEYVNGG-DLMFHMQ----RQRKL--PEEHARFYAAEICIALNFLHER-----GIIYRDLKLDNVLLD-ADGHI---KLTDYGMCKEG--------LGPGDTTSTFCGTPNYIAPEILR---GEEYGFSVDWWALGVLMFEMMAGRSPFDIITD-------NPDMNTEDYLFQVILEKPIRIPRFLS---------------------------------------VKASHVLKGFLNKDPKERLGCRPQTGF---------SDIKSHAFF-----
-PD----EVLGSGQFGIVYGGKHRKTGR-DVAIKIIDKLR-FPT---KQESQLRN------EVAILQNL-H---HPG--VVNLECMFET------PERVFVVMEKLHGD-MLEMILS---SEKGRL--PEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI---------IGEKSFRRSVVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLSGTFPFNED----------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS------VDKTLSHPWL--------------
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