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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL ACVR2A 203
TKL BRAF 456
TKL TGFBR1 205
-L-QLLEVKARGRFGCVWKAQLLNEY--VAVKIFPIQ-DKQSWQ--NEY--EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN--VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFE---AGKSAGDTHG---QVGTRRYMAPEVLEGAIN-----FQRD---AFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKK----RPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCV---GERI
--ITVGQRIGSGSFGTVYKGKWH---GDVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYST-----KPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK----------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK--S--R--WSGSHQFEQLSGSILWMAPEV----IR------MQDKNPYSFQSDVYAFGIVLYELMTGQ-----------LPYSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILASI---
IV--LQESIGKGRFGEVWRGKWRGEE--VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY--TVTVEGMIKLALSTASGLAHLHMEIVGT--QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS-ATDTIDIAPNH---RVGTKRYMAPEV----LDDSINMKHFE---SFKRADIYAMGLVFWEIARRCSIGGI-HEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK-TL--
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