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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ALK 203
TK ABL1 261
Other AURKA 133
TK EGFR 712
TK EPHA2 613
TK FGFR1 478
TK FGFR2 481
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK MERTK 587
TK MET 1078
TK MST1R 1082
TK PTK2 422
TK RET 724
TK SRC 270
STE STK24 24
TK TNK2 150
TK ZAP70 338
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL-QSLP-----RFILLELMAGGDLKSFLR-ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYY--RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV-TSGGRMDPPKNCP--GPVYRIMTQCWQHQPEDRPNFAIILER--I--
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-REPP-----FYIITEFMTYGNLLDYLR-EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM--T--GDTY--TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELL-EKDYRMERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F--
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--EHQLRREVEIQSHL-RHPNILRLYGYFH-DATR-----VYLILEYAPLGTVYRELQKLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV----HAPSSRR--TT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETY-KRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI--
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANKEIL-DEAYVMASV-DNPHVCRLLGICL--TST-----VQLITQLMPFGCLLDYVR-EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GA--EEKE--YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSIL-EKGERLPQPPICT--IDVYMIMVKCWMIDADSRPKFRELI----IEF
---V-TRQKVIGAGEFGEVYKGMLKT---SSGKKEVPVAIKTLK-A--G-YT-EKQRVDFL-GEAGIMGQF-SHHNIIRLEGVIS-KYKP-----MMIITEYMENGALDKFLR-EK-----------------------DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNS---NLVCKVSDFGLSRVL-ED--DPEA-TYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAI-NDGFRLPTPMDCP--SAIYQLMMQCWQQERARRPKFADIVSIL----
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLQ-ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI-HH--IDYY--KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLL-KEGHRMDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACT-QDGP-----LYVIVEYASKGNLREYLR-ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVMKIADFGLARDI-NN--IDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLL-KEGHRMDKPANCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-P--G-SM-SV--EAFL-AEANVMKTL-QHDKLVKLHAVVT--KEP-----IYIITEFMAKGSLLDFLK-SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI--E--DNEY--TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRAL-ERGYRMPRPENCP--EELYNIMMRCWKNRPEERPTFEYIQSV--L--
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS-QGQP-----TLVIMELMTRGDLKSYLR-SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI-YE--TDYY--RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV-MEGGLLDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I--
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-KGQP-----TLVVMELMAHGDLKSYLR-SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YE--TDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFV-MDGGYLDQPDNCP--ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
---L-ILGKILGEGEFGSVMEGNLK----QEDGTSLKVAVKTMKLD--N-SS-QREIEEFL-SEAACMKDF-SHPNVIRLLGVCI-EMSSQGIPKPMVILPFMKYGDLHTYLL-YSRL------------------ETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRD---DMTVCVADFGLSKKI-YS--GDYY--RQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYL-LHGHRLKQPEDCL--DELYEIMYSCWRTDPLDRPTFSVLRLQ--L--
----VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICLRSEGS-----PLVVLPYMKHGDLRNFIR-NE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDM-YD--KEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYL-LQGRRLLQPEYCP--DPLYEVMLKCWHPKAEMRPSFSELVSR--I--
-THS---DRVIGKGHFGVVYHGEYI----DQAQNRIQCAIKSLS-R--I-TE-MQQVEAFL-REGLLMRGL-NHPNVLALIGIMLPPEGL-----PHVLLPYMCHGDLLQFIR-SP-----------------------QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDE---SFTVKVADFGLARDI-LD--REYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFL-AQGRRLPQPEYCP--DSLYQVMQQCWEADPAVRPTFRVLV----GEV
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT--ENP-----VWIIMELCTLGELRSFLQ-VR-----------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM--E--DSTY--YKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRI-ENGERLPMPPNCP--PTLYSLMTKCWAYDPSRRPRFTELKAQL----
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS-QDGP-----LLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV-YE--EDSY--VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLL-KTGHRMERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS--EEP-----IYIVTEYMSKGSLLDFLK-GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--E--DNEY--TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--EDIQ-QEITVLSQC-DSPYVTKYYGSYL-KDTK-----LWIIMEYLGGGSALDLLE-PG-------------------------PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSE---HGEVKLADFGVAGQL--TDTQIKR--NT---FVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLI-PKNNPPTLEGNYS--KPLKEFVEACLNKEPSFRPTAKELLKHKFI--
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMDDFI-REVNAMHSL-DHRNLIRLYGVVL--TPP-----MKMVTELAPLGSLLDRLR-KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRALPQN--DDHY--VMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP--QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTEEMM-REAQIMHQL-DNPYIVRLIGVCQ--AEA-----LMLVMEMAGGGPLHKFLV-GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVN---RHYAKISDFGLSKALGAD--DSYY--TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFI-EQGKRMECPPECP--PELYALMSDCWIYKWEDRPDFLTVEQR--M--
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