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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
CAMK CASK 12
CMGC CDK2 4
CAMK DAPK1 13
TK EGFR 712
AGC GRK1 190
AGC GRK6 186
CAMK PIM1 38
CAMK PRKD1 583
AGC PRKG1 375
TK RET 724
----FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR----EVEIQSHLRHPN--ILRLYGYFHDATRVYLILEYAPLG-TVY-RELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI------------
----YELCEVIGKGPFSVVRRCINR-----ETGQQFAVKIVDVAK-FTSSP--GLSTEDL-KREASICHMLKHPH--IVELLETYSSDGMLYMVFEFMDGA-DLCFEIVKR-ADAGF-------------------------VYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL-GESGLVAGG---RVGTPHFMAPEVVK-REPYGKPVDVWGCGVILFILLS-GCLPFYGT-----KERLFEGIIKGKYKMNPRQWSHIS----------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL------------
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR----EISLLKELNHPN--IVKLLDVIHTENKLYLVFEFLHQ--DLK-KFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------------
----YDTGEELGSGQFAVVKKCREK-----STGLQYAAKFIKKRR-TKSSR--RGVSREDIEREVSILKEIQHPN--VITLHEVYENKTDVILILELVAGG-ELF-DFLA----EKE-------------------------SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK--IDFGNEFKN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASPFLGD----TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI------------
---F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D----EAYVMASVDNPH--VCRLLGICL-TSTVQLITQLMPFG-CLL-DYVR-----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHV----KITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF----------
FLDF----RVLGKGGFGEVSACQMK-----ATGKLYACKKLNKKR-LKKRK--GYQGAM---VEKKILMKVHSRF--IVSLAYAFETKADLCLVMTIMNGG-DIR-YHIYNVNEENP-------------------------GFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLD-NDGNV----RISDLGLAVEL-LDGQSKTKG---YAGTPGFMAPELLQ-GEEYDFSVDYFALGVTLYEMIA-ARGPFRARGEKVENKELKHRIISEPVKYPDKFS--------------------------QASKDFCEALLEKDPEKRLG-----FRD-------ETCDKLRAHPLF
---F-RQYRVLGKGGFGEVCACQVR-----ATGKMYACKKLEKKR-IKKRK--GEAMAL---NEKQILEKVNSRF--VVSLAYAYETKDALCLVLTLMNGG-DLK-FHIYH--MGQA-------------------------GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH--VPEGQTIKG---RVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIA-GQSPFQQR-KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF------------
----YQVGPLLGSGGFGSVYSGIRV-----SDNLPVAIKHVEKDR-ISDWG--ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLF-DFIT----ERG-------------------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA---LLKDTVYTD---FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD----------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM------------
--PD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKIIDKLR-FPTKQ--ESQLRN----EVAILQNLHHPG--VVNLECMFETPERVFVVMEKLHGD-MLE-MILS---SEKG-------------------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI--IGEKSFRRS---VVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED------EDIHDQIQNAAFMYPPNPWKEIS----------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL------------
---F-NIIDTLGVGGFGRVELVQLKS----EESKTFAMKILKKRH-IVDTR--QQEHIR---SEKQIMQGAHSDF--IVRLYRTFKDSKYLYMLMEACLGG-ELW-TILR----DRG-------------------------SFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD-HRGYA----KLVDFGFAKK--IGFGKKTWT---FCGTPEYVAPEIIL-NKGHDISADYWSLGILMYELLT-GSPPFSGP----DPMKTYNIILRGIDMIEFPKKIA------------------------KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF------------
---L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-EN-AS-PSELRDLL-S----EFNVLKQVNHPH--VIKLYGACSQDGPLLLIVEYAKYG-SLR-GFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM----KISDFGLSRDVYE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL--------------
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