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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
Other AURKB 77
TKL BRAF 456
CMGC CDC2 4
CMGC CDK2 4
TK ITK 363
TK JAK2 849
FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKA-QLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ---KLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISR----VEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKS-Q-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQ---KSC--TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-GRM---HNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVK----VDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
ITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLN-VTA-PT-PQQLQAFK-N-EVGVLRKTRHVNILLFMGYST---KPQLAIVTQWCEGSSLYHHLH----IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-SR--WSGSHQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP----------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI-
YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLE-S-EEEGV--PSTAIR-EISLLKELRHPNIVSLQDVLM--QDSRLYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLD-T-ETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
LTFVQEIGSGQFGLVHLGYWL-----NKDKVAIKTIR-E-G-AM-SE--EDFI-E-EAEVMMKLSHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR----TQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQYTSSTGTKFPVKWASPEVFS-FSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFR----LYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-H-S-TE--EHLRDFE-R-EIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGR----LPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
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