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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
TK EGFR 712
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK LCK 245
CMGC MAPK8 26
Other PLK4 12
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
TK TNK1 116
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVL---FKAQLEKAGV--EHQLRR-EVEIQSHL--RHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGEL---KIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTL---K-ED-TM-EV--EEFL-K-EAAVMKEI--KHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLV---KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTL---K-ED-TM-EV--EEFL-K-EAAVMKEI--KHPNLVQLLGVCTL------EPPFYIVTEYMPYGNLLDYLR----EC--------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVV---KVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLA-----YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP-----------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTL---P-EV-CS-EQDELDFL-M-EALIISKF--NHQNIVRCIGVSLQ------SLPRFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA---KIGDFGMARDI-YR--ASYYRKGGCAMLPVKWMPPEAFM-----EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP-----------------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVL---FKSQ-IEKEG--VEHQLRREIEIQAHL--HHPNILRLYNYFYD------RRRIYLILEYAPRGELYKELQ---KSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGEL---KIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV--
---FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVL---FKSQ-IEKEG--LEHQLRREIEIQAHL--QHPNILRLYNYFHD------ARRVYLILEYAPRGELYKELQ---KSE-----------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF---RGEV---KIADFGWSV----HTPSLRRKT---MCGTLDYLPPEMIE-----GRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMP---------------------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV--
--L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTL---K-EG-TM-SP--EAFL-G-EANVMKAL--QHERLVRLYAVVT-------KEPIYIVTEYMARGCLLDFLK----TD--------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCC---KIADFGLARII-----DSEYTAQEGAKFPIKWTAPEAIH-----FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCP-----------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMI---K-EG-SM-SE--DEFF-Q-EAQTMMKL--SHPKLVKFYGVCSK------EYPIYIVTEYISNGCLLNYLR----SH---------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR---DLCV---KVSDFGMTRYV--L--DDQYVSSVGTKFPVKWSAPEVFH-----YFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLAS-----------------------------------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I--
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMI---K-EG-SM-SE--DEFI-E-EAKVMMNL--SHEKLVQLYGVCTK------QRPIFIITEYMANGCLLNYLR----EM---------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVV---KVSDFGLSRYV--L--DDEYTSSVGSKFPVRWSPPEVLM-----YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLAS-----------------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKI---RLES-EEEGV--PSTAIR-EISLLKEL--RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTI---KLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRISGKMALNHPYF--
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLDT-ETEGV--PSTAIR-EISLLKEL--NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAI---KLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRISAKAALAHPFF--
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKEL---R-EA-TS-PKANKEIL-D-EAYVMASV--DNPHVCRLLGICL-------TSTVQLITQLMPFGCLLDYVR----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHV---KITDFGLAKLL-GA--EEKEYHAEGGKVPIKWMALESIL-----HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT-----------------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-SD-AT-EKDLSDLI-S-EMEMMKMIG-KHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVM---KIADFGLARDI-HH--IDYYKKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML---K-DD-AT-EKDLSDLV-S-EMEMMKMIG-KHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVM---KIADFGLARDI-NN--IDYYKKTTNGRLPVKWMAPEALF-----DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT-----------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML---K-DD-AT-DKDLSDLV-S-EMEMMKMIG-KHKNIINLLGACTQ------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE---DNVM---KIADFGLARDV-HN--LDYYKKTTNGRLPVKWMAPEALF-----DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT-----------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL----
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSL---K-QG-SM-SP--DAFL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSC---KIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKL---SRPF-QNQTH--AKRAYR-ELVLMKCV--NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTL---KILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRISVDEALQHPYI--
--F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMI---DKKA-MYKAG--MVQRVQNEVKIHCQL--KHPSILELYNYFED------SNYVYLVLEMCHNGEMNRYLK--NRVK-----------------PFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR---NMNI---KIADFGLATQL--KMPHEKHYT---LCGTPNYISPEIAT-----RSAHGLESDVWSLGCMFYTLLI-GRPPFDTD---TVKNTLNKVVLADYEMPSFLS---------------------------------------IEAKD-LIHQLLRRNPADRLSLSSVLDHPFM--
---WEIVGELGDGAFGKVYKAKNK-------ETGALAAAKVI---ETKS-EEELE--DYI--V-EIEILATC--DHPYIVKLLGAYYH------DGKLWIMIEFCPGGAVDAIML--ELDR-----------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTL---EGDI---RLADFGVSAKN--LKTLQKRDS---FIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ-IEPPHHELNPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV--
LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFM---RKRR-KGQDC--RMEIIH-EIAVLELA-QDNPWVINLHEVYET------ASEMILVLEYAAGGEIFDQCVA-DREE-----------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTS---ESPLGDIKIVDFGLSRI---LKNSEELRE---IMGTPEYVAPEILS-----YDPISMATDMWSIGVLTYVMLT-GISPFLGN---DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVD-FIRTLLVKKPEDRATAEECLKHPWL--
ILT---SKELGRGKFAVVRQCISK-------STGQEYAAKFL---KKRR-RGQDC--RAEILH-EIAVLELA-KSCPRVINLHEVYEN------TSEIILILEYAAGGEIFSLCLP-ELAE-----------------MVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSS---IYPLGDIKIVDFGMSRK---IGHACELRE---IMGTPEYLAPEILN-----YDPITTATDMWNIGIIAYMLLT-HTSPFVGE---DNQETYLNISQVNVDYSEETFSSVS-----------------------------------QLATD-FIQSLLVKNPEKRPTAEICLSHSWL--
VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-EG-PM-GTELGDFL-R-EVSVMMNL--EHPHVLRLHGLVL-------GQPLQMVMELAPLGSLHARLT----AP-------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS---PRTI---KVADFGLVRPLGGA--RGRYVMGGPRPIPYAWCAPESLR-----HGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCS-----------------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL
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