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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
Other AURKB 77
CMGC CDK2 4
TK EGFR 712
TK NTRK1 510
Other PLK1 53
--FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ--KLS----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
--ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLR---EC-------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQ--KSC----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV---HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKEIL-D-EAYVMASVDNPHVCRLLGICL-TSTVQLITQLMPFGCLLDYVR---EH--------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EA-SE-SA-RQDFQ-R-EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR---SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS--TDYYRVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACP----------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL----
YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIVPKSL-LLKPH--QREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHK--RRK----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV-EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
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