|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ALK 1116
Other AURKB 77
TKL BRAF 456
TK EGFR 712
TK JAK3 822
TK LCK 245
CMGC MAPK10 64
CMGC MAPK8 26
AGC PDPK1 82
TK TEK 824
-FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKA-QLEKAGV--EH-QLRR-EVEIQSHL-RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQKLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIEGRM---HDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN----TYQETYKRISR----VEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-E-D-TM-EV--EE-FL-K-EAAVMKEI-KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSP-------------YPGI-DLSQVYELLEKDYR----MERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-E-V-CS-EQDELD-FL-M-EALIISKF-NHQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR-ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI--Y-R--ASYYRKGGCAMLPVKWMPPEAFMEGI---FTSKTDTWSFGVLLWEIFSLGYMP-------------YPSK-SNQEVLEFVTSGGR----MDPPKNCP-----------------------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I-----------
-FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKS-Q-IEKEG--VE-HQLRREIEIQAHL-HHPNILRLYNYFY--D------RRRIYLILEYAPRGELYKELQKSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIEGRM---HNEKVDLWCIGVLCYELLV-GNPP-------------FESA----SHNETYRRIVK----VDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
-ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLN-VTA-PT-PQQLQA-FK-N-EVGVLRKT-RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH-II---------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK--S-R--WSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLP-------------YSNINNRDQIIFMVGRGYLSPDLSKVRSNCP-----------------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI----------
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E-A-TS-PKANKE-IL-D-EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESILHRI---YTHQSDVWSYGVTVWELMTFGSKP-------------YDGI-PASEISSILEKGER----LPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-H-S-GP-DQ-QRD-FQ-R-EIQILKAL-HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLSDNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQR----LPAPPACP-----------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
-LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q-G-SM-SP--DA-FL-A-EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIP-------------YPGM-TNPEVIQNLERGYR----MVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
-YQNLKPIGSGAQGIVCAAYDA-----VLDRNVAIKKLSRP-F-QNQTH--AK-RAYR-ELVLMKCV-NHKNIISLLNVFT--PQKTLEEFQDVYLVMELMDA-NLCQVIQ--M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVILGMG---YKENVDIWSVGCIMGEMVR-HKIL-------------FPGR-DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-----------
-YQNLKPIGSGAQGIVCAAYDA-----ILERNVAIKKLSRP-F-QNQTH--AK-RAYR-ELVLMKCV-NHKNIIGLLNVFT--PQKSLEEFQDVYIVMELMDA-NLCQVIQ--M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVILGMG---YKENVDLWSVGCIMGEMVC-HKIL-------------FPGR-DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKR-H-IIKEN--KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQ--D------DEKLYFGLSYAKNGELLKYIRKIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNE---DMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLTEKS---ACKSSDLWALGCIIYQLVA-GLPP-------------FRAG----NEYLIFQKIIK----LEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMK-E-Y-AS-KDDHRD-FA-G-ELEVLCKLGHHPNIINLLGACE--H------RGYLYLAIEYAPHGNLLDFLR-KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ--------EVYVKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTP-------------YCGM-TCAELYEKLPQGYR----LEKPLNCD-----------------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL----------
|