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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TKL BRAF 456
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK CSK 195
CMGC CSNK2A1 39
CAMK DAPK2 23
TK EGFR 712
TK EPHA3 621
TK EPHB1 619
TK FER 563
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK JAK2 849
TK LCK 245
TKL LIMK1 339
CMGC MAPK10 64
CMGC MAPK8 26
CAMK MAPKAPK5 22
Other PLK4 12
TK PTK2B 425
CAMK SIK1 27
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
TK TEC 370
TK TEK 824
TK TIE1 839
TK TNK1 116
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVL---FKA-QLEKA---GV--EHQLRR----EVEIQSHL--R---HPNILRLYGYFH--D----------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-S---AGEL----KIADFGWSV------HAPSSRR------------TT---LCGTLDYLPPEMIE------------------GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN------TYQETYKRISR----VEFTFPDFVT---------------------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTL---K-E-D-TM----EV--EEFL-K----EAAVMKEI--K---HPNLVQLLGVCT--R----------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-E---NHLV----KVADFGLSRLM----T--GDTY------------TAHAGAKFPIKWTAPESLA------------------YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI---DLSQVYELLEKDYR----MERPEGCP-----------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTL---K-E-D-TM----EV--EEFL-K----EAAVMKEI--K---HPNLVQLLGVCT--L----------EPPFYIVTEYMPYGNLLDYLR----EC--------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-E---NHVV----KVADFGLSRLM----T--GDTY------------TAHAGAKFPIKWTAPESLA------------------YNT---FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI---DLSQVYDLLEKGYR----MEQPEGCP-----------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTL---P-E-V-CS----EQDELDFL-M----EALIISKF--N---HQNIVRCIGVSL--Q----------SLPRFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT-CPGPGRVA----KIGDFGMARDI---YR--ASYY------------RKGGCAMLPVKWMPPEAFM------------------EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YP-SK---SNQEVLEFVTSGGR----MDPPKNCP-----------------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVL---FKS-Q-IEK---EG--VEHQLR---REIEIQAHL--H---HPNILRLYNYFY--D----------RRRIYLILEYAPRGELYKELQ---KSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-L---KGEL----KIADFGWSV------HAPSLRR------------KT---MCGTLDYLPPEMIE------------------GRM---HNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA------SHNETYRRIVK----VDLKFPASVP---------------------------------------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV--
---FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVL---FKS-Q-IEK---EG--LEHQLR---REIEIQAHL--Q---HPNILRLYNYFH--D----------ARRVYLILEYAPRGELYKELQ---KSE-----------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-F---RGEV----KIADFGWSV------HTPSLRR------------KT---MCGTLDYLPPEMIE------------------GRT---YDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA------SHSETYRRILK----VDVRFPLSMP---------------------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV--
--L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTL---K-E-G-TM----SP--EAFL-G----EANVMKAL--Q---HERLVRLYAVVT-------------KEPIYIVTEYMARGCLLDFLK----TD--------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVS-E---ALCC----KIADFGLARII-------DSEY------------TAQEGAKFPIKWTAPEAIH------------------FGV---FTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM---SNPEVIRNLERGYR----MPRPDTCP-----------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMI---K-E-G-SM----SE--DEFF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K----------EYPIYIVTEYISNGCLLNYLR----SH---------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD-R---DLCV----KVSDFGMTRYV----L--DDQY------------VSSVGTKFPVKWSAPEVFH------------------YFK---YSSKSDVWAFGILMWEVFSLGKQP---------------YD-LY---DNSQVVLKVSQGHR----LYRPHLAS-----------------------------------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I--
---ITVGQRIGSGSFGTVYKGKWH----------GDVAVKML---N-VTA-PT----PQQLQAFK-N----EVGVLRKT--R---HVNILLFMGYST-------------KPQLAIVTQWCEGSSLYHHLH----II---------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLH-E---DLTV----KIGDFGLATVK---SR--WSGS------------HQFEQLSGSILWMAPEVIR------------------MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YS-NI-N-NRDQIIFMVGRGYLSPDLSKVRSNCP-----------------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI-
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMI---K-E-G-SM----SE--DEFI-E----EAKVMMNL--S---HEKLVQLYGVCT--K----------QRPIFIITEYMANGCLLNYLR----EM---------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-D---QGVV----KVSDFGLSRYV----L--DDEY------------TSSVGSKFPVRWSPPEVLM------------------YSK---FSSKSDIWAFGVLMWEIYSLGKMP---------------YE-RF---TNSETAEHIAQGLR----LYRPHLAS-----------------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKI---RLE-S-EEE---GV--PSTAIR----EISLLKEL--R---HPNIVSLQDVLM--Q----------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-D---KGTI----KLADFGLARAF----GIPIRVY------------TH---EVVTLWYRSPEVLL-----------------GSAR---YSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD---SEIDQLFRIFRALG----TPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRISGKMALNHPYF--
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLD-T-ETE---GV--PSTAIR----EISLLKEL--N---HPNIVKLLDVIH--T----------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-T---EGAI----KLADFGLARAF----GVPVRTY------------TH---EVVTLWYRAPEILL-----------------GCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD---SEIDQLFRIFRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRISAKAALAHPFF--
--Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSV---RVP-N-GGGGGGGL--PISTVR----EVALLRRL--EAFEHPNVVRLMDVCA--TSR-----TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-S---GGTV----KLADFGLARI-----YSYQMAL------------TP---VVVTLWYRAPEVLL------------------QST---YATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN---SEADQLGKIFDLIG----LPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFRALQHSYL--
---LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCI---K-N-D-AT----AQ---AFL-A----EASVMTQL--R---HSNLVQLLGVIV-EE----------KGGLYIVTEYMAKGSLVDYLR----SR--------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS-E---DNVA----KVSDFGLTKEA----------S------------STQDTGKLPVKWTAPEALR------------------EKK---FSTKSDVWSFGILLWEIYSFGRVP---------------YP-RI---PLKDVVPRVEKGYK----MDAPDGCP-----------------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----
---YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKIL---KPV-K-KKK---IK--R---------EIKILENL-RG---GPNIITLADIVK--DP--------VSRTPALVFEHVNNTDFKQLY------Q-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHE---HRKL----RLIDWGLAEF-----YHPGQEY------------NV---RVASRYFKGPELLV-----------------DYQM---YDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH---DNYDQLVRIAKVLG----TEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLTAREAMEHPYF--
---YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFI---KKR-Q-SRA---SR--RGVSREEIEREVSILRQV--L---HHNVITLHDVYE--N----------RTDVVLILELVSGGELFDFLA---QKE-----------------SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL-D---KNIPIPHIKLIDFGLAHE-----IEDGVEF------------KN---IFGTPEFVAPEIVN------------------YEP---LGLEADMWSIGVITYILLS-GASP---------------FL-GD------TKQETLANITA----VSYDFDEEFFSQTS-----------------------------------ELAKD-FIRKLLVKETRKRLTIQEALRHPWI--
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKEL---R-E-A-TS----PKANKEIL-D----EAYVMASV--D---NPHVCRLLGICL-------------TSTVQLITQLMPFGCLLDYVR----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-T---PQHV----KITDFGLAKLL---GA--EEKE------------YHAEGGKVPIKWMALESIL------------------HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YD-GI---PASEISSILEKGER----LPQPPICT-----------------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF
--I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTL---K-V-G-YT----EKQRRDFL-G----EASIMGQF--D---HPNIIRLEGVVT--K----------SKPVMIVTEYMENGSLDSFLR----KH---------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILIN-S---NLVC----KVSDFGLSRVL---ED--DPEA-----------AYTTRGGKIPIRWTSPEAIA------------------YRK---FTSASDVWSYGIVLWEVMSYGERP---------------YW-EM---SNQDVIKAVDEGYR----LPPPMDCP-----------------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL----
--V-KIEEVIGAGEFGEVYKGRLK----LPGKREIYVAIKTL---K-A-G-YS----EKQRRDFL-S----EASIMGQF--D---HPNIIRLEGVVT--K----------SRPVMIITEFMENGALDSFLR----QN---------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVN-S---NLVC----KVSDFGLSRYLQDDTS--DPTY------------TSSLGGKIPVRWTAPEAIA------------------YRK---FTSASDVWSYGIVMWEVMSFGERP---------------YW-DM---SNQDVINAIEQDYR----LPPPMDCP-----------------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----
-VI--LGELLGKGNFGEVYKGTLK--------DKTSVAVKTC---K-E-D-LP----QELKIKFL-Q----EAKILKQY--D---HPNIVKLIGVCT--Q----------RQPVYIIMELVSGGDFLTFLR----RK---------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVG-E---NNVL----KISDFGMSRQE----D--GGVY------------SSSGLKQIPIKWTAPEALN------------------YGR---YSSESDVWSFGILLWETFSLGVCP---------------YP-GM---TNQQAREQVERGYR----MSAPQHCP-----------------------------------------EDISK-IMMKCWDYKPENRPKFSELQKEL----
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-S-D-AT----EKDLSDLI-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-E---DNVM----KIADFGLARDI---HH--IDYY------------KKTTNGRLPVKWMAPEALF------------------DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV---PVEELFKLLKEGHR----MDKPSNCT-----------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML---K-D-D-AT----EKDLSDLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT-E---NNVM----KIADFGLARDI---NN--IDYY------------KKTTNGRLPVKWMAPEALF------------------DRV---YTHQSDVWSFGVLMWEIFTLGGSP---------------YP-GI---PVEELFKLLKEGHR----MDKPANCT-----------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML---K-D-D-AT----DKDLSDLV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVT-E---DNVM----KIADFGLARDV---HN--LDYY------------KKTTNGRLPVKWMAPEALF------------------DRV---YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GI---PVEELFKLLKEGHR----MDKPANCT-----------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL----
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKL---Q-H-S-TE-----EHLRDFE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRNLKLIMEYLPYGSLRDYLQ----KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-N---ENRV----KIGDFGLTKVL--PQD--KEYY------------KVKEPGESPIFWYAPESLT------------------ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM---IVFHLIELLKNNGR----LPRPDGCP-----------------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSL---K-Q-G-SM----SP--DAFL-A----EANLMKQL--Q---HQRLVRLYAVVT-------------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-D---TLSC----KIADFGLARLI----E--DNEY------------TAREGAKFPIKWTAPEAIN------------------YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM---TNPEVIQNLERGYR----MVRPDNCP-----------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
-LI--HGEVLGKGCFGQAIKVTHR-------ETGEVMVMKEL---I---R-FD----EETQRTFL-K----EVKVMRCL--E---HPNVLKFIGVLY--K----------DKRLNFITEYIKGGTLRGIIK----SM---------------DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVR-E---NKNV----VVADFGLARLM---VD--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN------------------GRS---YDEKVDVFSFGIVLCEIIGRVNAD---------------PD-YL-P-RTMDFGLNVRGFLD----RYCPPNCP-----------------------------------------PSFFP-ITVRCCDLDPEKRPSFVKLEH---WL-
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKL---SRP-F-QNQ---TH--AKRAYR----ELVLMKCV--N---HKNIISLLNVFT--PQKT----LEEFQDVYLVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-S---DCTL----KILDFGLART-----AGTSFMM------------TP---YVVTRYYRAPEVIL------------------GMG---YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR---DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRISVDDALQHPYI--
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKL---SRP-F-QNQ---TH--AKRAYR----ELVLMKCV--N---HKNIIGLLNVFT--PQKS----LEEFQDVYIVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-S---DCTL----KILDFGLART-----AGTSFMM------------TP---YVVTRYYRAPEVIL------------------GMG---YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR---DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRISVDEALQHPYI--
INW---TQKLGAGISGPVRVCVKK-------STQERFALKIL---LDR-P-KAR------------N----EVRLHMMC-AT---HPNIVQIIEVFA--NSVQFPHESSPRARLLIVMEMMEGGELFHRIS---QHR-----------------HFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFK-D---NS-LDAPVKLCDFGFAK-------IDQGDL------------MT---PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT---YNKSCDLWSLGVIIYVMLC-GYPP---------------FY-SKH-HSRTIPKDMRRKIMT----GSFEFPEEEWSQIS-----------------------------------EMAKD-VVRKLLKVKPEERLTIEGVLDHPWL--
--F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMI---DKK-A-MYK---AG--MVQRVQ---NEVKIHCQL--K---HPSILELYNYFE--D----------SNYVYLVLEMCHNGEMNRYLK--NRVK-----------------PFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT-R---NMNI----KIADFGLATQL----KMPHEKH------------YT---LCGTPNYISPEIAT------------------RSA---HGLESDVWSLGCMFYTLLI-GRPP---------------FD-TD------TVKNTLNKVVL----ADYEMPSFLS---------------------------------------IEAKD-LIHQLLRRNPADRLSLSSVLDHPFM--
--V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTC---K-K-D-CT----LDNKEKFM-S----EAVIMKNL--D---HPHIVKLIGIIE-------------EEPTWIIMELYPYGELGHYLE----RN---------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-S---PECV----KLGDFGLSRYI----E--DEDY------------YKASVTRLPIKWMSPESIN------------------FRR---FTTASDVWMFAVCMWEILSFGKQP---------------FF-WL---ENKDVIGVLEKGDR----LPKPDLCP-----------------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L--
---YDIERTLGKGNFAVVKLARHR-------VTKTQVAIKII---DKT-R-LDS---SN--LEKIYR----EVQLMKLL--N---HPHIIKLYQVME--T----------KDMLYIVTEFAKNGEMFDYLT---SNG-----------------HLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLD-G---NMDI----KLADFGFGNF-----YKSGEPL------------ST---WCGSPPYAAPEVFE-----------------GKEY---EGPQLDIWSLGVVLYVLVC-GSLP---------------FD-GP------NLPTLRQRVLE----GRFRIPFFMS---------------------------------------QDCES-LIRRMLVVDPARRITIAQIRQHRWM--
---WEIVGELGDGAFGKVYKAKNK-------ETGALAAAKVI---ETK-S-EEE---LE--DYI--V----EIEILATC--D---HPYIVKLLGAYY--H----------DGKLWIMIEFCPGGAVDAIML--ELDR-----------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMT-L---EGDI----RLADFGVSAKN----LKTLQKR------------DS---FIGTPYWMAPEVVMCE-------------TMKDTP---YDYKADIWSLGITLIEMAQ-IEPP---------------HH-EL---NPMRVLLKIAKSDP----PTLLTPSKWS---------------------------------------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV--
LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFM---RKR-R-KGQ---DC--RMEIIH----EIAVLELA-QD---NPWVINLHEVYE--T----------ASEMILVLEYAAGGEIFDQCVA-DREE-----------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-S---ESPLG-DIKIVDFGLSRI-----LKNSEEL------------RE---IMGTPEYVAPEILS------------------YDP---ISMATDMWSIGVLTYVMLT-GISP---------------FL-GN------DKQETFLNISQ----MNLSYSEEEFDVLS-----------------------------------ESAVD-FIRTLLVKKPEDRATAEECLKHPWL--
ILT---SKELGRGKFAVVRQCISK-------STGQEYAAKFL---KKR-R-RGQ---DC--RAEILH----EIAVLELA-KS---CPRVINLHEVYE--N----------TSEIILILEYAAGGEIFSLCLP-ELAE-----------------MVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-S---IYPLG-DIKIVDFGMSRK-----IGHACEL------------RE---IMGTPEYLAPEILN------------------YDP---ITTATDMWNIGIIAYMLLT-HTSP---------------FV-GE------DNQETYLNISQ----VNVDYSEETFSSVS-----------------------------------QLATD-FIQSLLVKNPEKRPTAEICLSHSWL--
---LTFMRELGSGLFGVVRLGKWR--------AQYKVAIKAI---R-E-G-AM----CE--EDFI-E----EAKVMMKL--T---HPKLVQLYGVCT--Q----------QKPIYIVTEFMERGCLLNFLR----QR---------------QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVS-E---AGVV----KVSDFGMARYV----L--DDQY------------TSSSGAKFPVKWCPPEVFN------------------YSR---FSSKSDVWSFGVLMWEVFTEGRMP---------------FE-KY---TNYEVVTMVTRGHR----LYQPKLAS-----------------------------------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I--
---IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRM---K-E-Y-AS----KDDHRDFA-G----ELEVLCKLG-H---HPNIINLLGACE--H----------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-E---NYVA----KIADFGLSRGQ--------EVY------------VKKTMGRLPVRWMAIESLN------------------YSV---YTTNSDVWSYGVLLWEIVSLGGTP---------------YC-GM---TCAELYEKLPQGYR----LEKPLNCD-----------------------------------------DEVYD-LMRQCWREKPYERPSFAQILV---SL-
---ITFEDLIGEGNFGQVIRAMIK-----KDGLKMNAAIKML---K-E-Y-AS----ENDHRDFA-G----ELEVLCKLG-H---HPNIINLLGACK--N----------RGYLYIAIEYAPYGNLLDFLR----KSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVG-E---NLAS----KIADFGLSRGE--------EVY------------VKKTMGRLPVRWMAIESLN------------------YSV---YTTKSDVWSFGVLLWEIVSLGGTP---------------YC-GM---TCAELYEKLPQGYR----MEQPRNCD-----------------------------------------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L--
VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-E-G-PM----GTELGDFL-R----EVSVMMNL--E---HPHVLRLHGLVL-------------GQPLQMVMELAPLGSLHARLT----AP-------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLA-S---PRTI----KVADFGLVRPL--GGA--RGRY------------VMGGPRPIPYAWCAPESLR------------------HGA---FSSASDVWMFGVTLWEMFSGGEEP---------------WA-GV---PPYLILQRLEDRAR----LPRPPLCS-----------------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL
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