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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
CMGC CSNK2A1 39
TK EGFR 712
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK8 26
AGC PDPK1 82
Other PLK1 53
Other PLK3 62
TK PTK2 422
--FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKAGV--EH-QLRR-EVEIQSHL-RHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
--YQLVRKLGRGKYSEVFEAINI----TNNEKVVVKILKPVK-KKKIK--R-------EIKILENLRGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF----YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF-----------
-F-KKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EA-TS-PKANKE-IL-D-EAYVMASV-DNPHVCRLLGICL-------TSTVQ--LITQLMPFG--CLLDYVR-----EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHVKITDFGLAKLL-G-A--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYD-GIPASEISSILEKGERLPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF---------
--YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDK-RFKNR----------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
--YQNLKPIGSGAQGIVCAAYDA----VLDRNVAIKKLSRPF-QNQTH--AK-RAYR-ELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-----------
--YQNLKPIGSGAQGIVCAAYDA----ILERNVAIKKLSRPF-QNQTH--AK-RAYR-ELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
-F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRH-IIKEN--KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIG--SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
YV--RGRFLGKGGFAKCFEISDA----DTKEVFAGKIVPKSL-LLKPH--QR-EKMSMEISIHRSL-AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK--ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV---EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
YL--KGRLLGKGGFARCYEATDT----ETGSAYAVKVIPQSR-VAKPH--QR-EKILNEIELHRDL-QHRHIVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK----ARH--TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMELKVGDFGLAARL---EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFE-TA---DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-----------
--IELGRCIGEGQFGDVHQGIYM-SPENPALAVAIKTCK-NC-TS-DSVREK-FL-Q-EALTMRQF-DHPHIVKLIGVIT-------ENPVW--IIMELCTLG--ELRSFLQ-----VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS-SNDCVKLGDFGLSRYM---E--DSTYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQ-GVKNNDVIGRIENGERLPMPPNCP-----------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
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