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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ALK 1116
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
-FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKA---GV--EHQLRREVEIQSHLR---HPNILRLYGYFHD-----ATRVYLILEYAPLGTVYRELQ---KLS--------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EV-CS----EQDELDFL-MEALIISKFN---HQNIVRCIGVSLQ-----SLPRFILLELMAGGDLKSFLR----ETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR--ASYYRKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I
-YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLES-EEE---GV--PSTAIREISLLKELR---HPNIVSLQDVLMQ-----DSRLYLIFEFLSM-DLKKYLDSIPPGQ--------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETE---GV--PSTAIREISLLKELN---HPNIVKLLDVIHT-----ENKLYLVFEFLHQ-DLKKFMDA-SALT--------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Y-EPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPN-GGGGGGGL--PISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDK-APPP--------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARI--YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
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