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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BTK 203
TK ABL1 261
TK ALK 1116
TK BMX 422
TK EGFR 712
TK EPHB1 619
TK EPHB4 615
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FLT4 845
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK KDR 834
TK KIT 589
TK LCK 245
TK LYN 247
TK MET 1078
TK NTRK2 538
TK PDGFRA 593
TK PDGFRB 600
TK RET 724
TK ROS1 1945
TK SRC 270
TK SYK 371
TK TYK2 589
TK YES1 277
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIKEGSMSE---DEFIEEAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLREM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND-----QGVVKVSDFGLSRYV----LDDEY--TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSN-I--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLKEDTMEV---EEFLKEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE-----NHLVKVADFGLSRLM----TGDTY--TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLPEVCSEQD-ELDFLMEALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLRETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP--GPGRVAKIGDFGMARDI---YRASYY--RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILER-I--
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMIKEGSMSE---DEFFQEAQTMMKL-SHPKLVKFYGVCS--KEYPIYIVTEYISNGCLLNYLRSH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR-----DLCVKVSDFGMTRYV----LDDQY--VSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQP---------------YDLY-DNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSS-I--
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELREATSPKA-NKEILDEAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVREH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT-----PQHVKITDFGLAKLL---GAEEKE--YHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELI---IEF
--V-KIEEVIGAGEFGEVYKGRLK----LPGKREIYVAIKTLKAGYSEKQ-RRDFLSEASIMGQF-DHPNIIRLEGVVT--KSRPVMIITEFMENGALDSFLRQN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS-----NLVCKVSDFGLSRYLQDDTSDPTY--TSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL---
--V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLKGGYTERQ-RREFLSEASIMGQF-EHPNIIRLEGVVT--NSMPVMILTEFMENGALDSFLRLN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNS-----NLVCKVSDFGLSRFLEENSSDPTY--TSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERP---------------YWDM-SNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL---
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKD-LSDLVSEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLRARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE-----NNVMKIADFGLARDI---NNIDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD-LSDLVSEMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLRARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE-----DNVMKIADFGLARDV---HNLDYY--KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL---
--L-VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKD-LADLVSEMEVMKLIGRHKNIINLLGVCT--QEGPLYVIVECAAKGNLREFLRARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTE-----DNVMKIADFGLARGV---HHIDYY--KKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSP---------------YPGI-PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL---
---LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLKEGATASE-HRALMSELKILIHIGNHLNVVNLLGACT-KPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSE-----SDVVKICDFGLARDI---YKDPDY--VRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP---------------YPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL---
---LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLKPGTMSP---ESFLEEAQIMKKL-KHDKLVQLYAVVS---EEPIYIVTEYMNKGSLLDFLKDG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN-----GLICKIADFGLARLI----EDNEY--TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM-NNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFL---
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMKPGSMSV---EAFLAEANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA-----SLVCKIADFGLARVI----EDNEY--TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSV-L--
---ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVNEAASMRE-RIEFLNEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLRSLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE-----DFTVKIGDFGMTRDI---YETDYY--RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I--
---ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVNESASLRE-RIEFLNEASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLRSLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH-----DFTVKIGDFGMTRDI---YETDYY--RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL---
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQHSTE-EH-LRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN-----ENRVKIGDFGLTKVL--PQDKEYY--KVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
---LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLKEGATHSE-HRALMSELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE-----KNVVKICDFGLARDI---YKDPDY--VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
---LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLKPSAHLTE-REALMSELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH-----GRITKICDFGLARDI---KNDSNY--VVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I--
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLKQGSMSP---DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD-----TLSCKIADFGLARLI----EDNEY--TAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
---IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLKPGTMSV---QAFLEEANLMKTL-QHDKLVRLYAVVT--REEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE-----SLMCKIADFGLARVI----EDNEY--TAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSV-L--
---VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLNRITDIGE-VSQFLTEGIIMKDF-SHPNVLSLLGICL-RSEGSPLVVLPYMKHGDLRNFIRNE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE-----KFTVKVADFGLARDM---YDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I--
--I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLKDASDNA--RKDFHREAELLTNL-QHEHIVKFYGVCV--EGDPLIMVFEYMKHGDLNKFLRAHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE-----NLLVKIGDFGMSRDV---YSTDYY--RVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-SNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL-L--
--L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLKPTARSSE-KQALMSELKIMTHLGPHLNIVNLLGACT--KSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ-----GKIVKICDFGLARDI---MHDSNY--VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTP---------------YPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE--IV-
--L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLKSTARSSE-KQALMSELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE-----GKLVKICDFGLARDI---MRDSNY--ISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL--LL-
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLKENASPSE-LRDLLSEFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE-----GRKMKISDFGLSRDV---YEEDSY--VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL---
-LT--LRLLLGSGAFGEVYEGTAVDI-LGVGSGEIKVAVKTLKKGSTDQE-KIEFLKEAHLMSKF-NHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLRKARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI---YKNDYY--RKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQP---------------YPAH-SNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQL---
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKPGTMSP---EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE-----NLVCKVADFGLARLI----EDNEY--TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT-----QHYAKISDFGLSKAL---RADENY-YKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE---LRL
--L-KKIRDLGEGHFGKVSLYCYDP---TNDGTGEMVAVKALKADCGPQH-RSGWKQEIDILRTL-YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDN-----DRLVKIGDFGLAKAV--PEGHEYY--RVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKF-LELIGIAQGQM-TVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIP--IL-
--L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLKPGTMMP---EAFLQEAQIMKKL-RHDKLVPLYAVVS---EEPIYIVTEFMSKGSLLDFLKEG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE-----NLVCKIADFGLARLI----EDNEY--TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGM-VNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL---
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