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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CAMK2A 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CDK6 13
CAMK CHEK2 220
CMGC CLK3 156
CMGC CSNK2A2 40
AGC PRKG1 375
AGC PRKG2 453
--YQLFEELGKGAFSVVRRCVKV-LAGQ-EYAAKIINTKK-LSARDHQKLER-------------------------EARICRLL-K---HPN---IVRLHDSISE-----EGHHYLIFDLVTGGELFEDIV---AREYY---SEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKLKGA-----------------AVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR---KDP--YGKPVDLWACGVILYILLV-GYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT-------------------------------------PEAKDLINKMLTINPSKRIT-----AAEALKHPWI
--FEIGRPLGKGKFGNVYLAREK-QSKF-ILALKVLFKAQLEKAGVEHQLRR-------------------------EVEIQSHL-R---HPN---ILRLYGYFHD-----ATRVYLILEYAPLGTVYRELQ---KLSKF---DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL--------------------KIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE---GRM--HDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI
--FEIGRPLGKGKFGNVYLAREK-KSHF-IVALKVLFKSQ-IEKEGVEHQLR------------------------REIEIQAHL-H---HPN---ILRLYNYFYD-----RRRIYLILEYAPRGELYKELQ---KSCTF---DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL--------------------KIADFGWSV--HAPSLRRKTMCGTLDYLPPEMIE---GRM--HNEKVDLWCIGVLCYELLV-GNPPFE-SA---SHNETYRRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV
--FEIGRPLGKGKFGNVYLARLK-ESHF-IVALKVLFKSQ-IEKEGLEHQLR------------------------REIEIQAHL-Q---HPN---ILRLYNYFHD-----ARRVYLILEYAPRGELYKELQ---KSEKL---DEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEV--------------------KIADFGWSV--HTPSLRRKTMCGTLDYLPPEMIE---GRT--YDEKVDLWCIGVLCYELLV-GYPPFE-SA---SHSETYRRILKVDVRFPLSMP-----------------------------------------LGARDLISRLLRYQPLERLP-----LAQILKHPWV
--YKLQSEIGKGAYGVVRLAYNE-SEDR-HYAMKVLSKKK-LLKQYGFPR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL-D---HVN---VVKLIEVLDDP---AEDNLYLVFDLLRKGPVMEVPC----DKPF---SEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-DDGHV--------------------KIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSF--SGKALDVWATGVTLYCFVY-GKCPFI-DD---FILALHRKIKNEPVVFPEEPEIS---------------------------------------EELKDLILKMLDKNPETRIG-----VPDIKLHPWV
--YTLKDEIGKGSYGVVKLAYNE-NDNT-YYAMKVLSKKK-LIRQAGFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D---HPN---VVKLVEVLDDP---NEDHLYMVFELVNQGPVMEVPT----LKPL---SEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHI--------------------KIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS--ETRKIFSGKALDVWAMGVTLYCFVF-GQCPFM-DE---RIMCLHSKIKSQALEFPDQPDIA---------------------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV
--YTKIEKIGEGTYGVVYKGRHK-TTGQ-VVAMKKIRLES-EEEGVPSTAIR-------------------------EISLLKEL-R---HPN---IVSLQDVLMQ-----DSRLYLIFEFLSM-DLKKYLDSIPPGQYM---DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI--------------------KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL--GSAR--YSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF
--FQKVEKIGEGTYGVVYKARNK-LTGE-VVALKKIRLDT-ETEGVPSTAIR-------------------------EISLLKEL-N---HPN---IVKLLDVIHT-----ENKLYLVFEFLHQ-DLKKFMDA-SALTGI---PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI--------------------KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILL--GCKY--YSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
--YEKLEKIGEGTYGTVFKAKNR-ETHE-IVALKRVRLDD-DDEGVPSSALR-------------------------EICLLKEL-K---HKN---IVRLHDVLHS-----DKKLTLVFEFCDQ-DLKKYFD--SCNGDL---DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL--------------------KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF--GAKL--YSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF
--YECVAEIGEGAYGKVFKARDL-KNGGRFVALKRVRVQT-GEEGMPLSTIR-------------------------EVAVLRHL-ETFEHPN---VVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDK-VPEPGV---PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI--------------------KLADFGLARI-YSFQMALTSVVVTLWYRAPEVLL---QSS--YATPVDLWSVGCIFAEMFR-RKPLFR-GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF
YI--MSKTLGSGACGEVKLAFER-KTCK-KVAIKIISKRK-FAIGSAREADPALN-------------------VETEIEILKKL-N---HPC---IIKIKNFF-D-----AEDYYIVLELMEGGELFDKVV---GNKRL---KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-----------------LIKITDFGHSKI-LGETSLMRTLCGTPTYLAPEVLVSVGTAG--YNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL
--YEIVGNLGEGTFGKVVECLDH-ARGKSQVALKIIRNVG-KYREAAR---L-------------------------EINVLKKI-KEKDKENKFLCVLMSDWFNF-----HGHMCIAFELLGK-NTFEFLK----ENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV-NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT---FDHEHHTTIVATRHYRPPEVIL---ELG--WAQPCDVWSIGCILFEYYR-GFTLFQ-THENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-----LAEALLHPFF
--YQLVRKLGRGKYSEVFEAINI-TNNE-RVVVKILKPVK-KKKIKR------------------------------EVKILENLRG---GTN---IIKLIDTVKDP---VSKTPALVFEYINNTDFKQLY------QIL---TDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL--------------------RLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLV--DYQM--YDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAMEHPYF
-F-NIIDTLGVGGFGRVELVQLKSEESK-TFAMKILKKRH-IVDTRQQEHIR------------------------SEKQIMQGA-H---SDF---IVRLYRTFKD-----SKYLYMLMEACLGGELWTILR---DRGSF---EDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILD-HRGYA--------------------KLVDFGFAKK-IGFGKKTWTFCGTPEYVAPEIIL---NKG--HDISADYWSLGILMYELLT-GSPPFS-GP---DPMKTYNIILRGIDMIEFPKKIA---------------------------------------KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF
-L-EIIATLGVGGFGRVELVKVK-NENV-AFAMKCIRKKH-IVDTKQQEHVY------------------------SEKRILEEL-C---SPF---IVKLYRTFKD-----NKYVYMLLEACLGGELWSILR---DRGSF---DEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILD-AEGYL--------------------KLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVIL---NKG--HDFSVDFWSLGILVYELLT-GNPPFS-GV---DQMMTYNLILKGIEKMDFPRKIT---------------------------------------RRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL
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