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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CAMK2B 203
Other AURKA 133
Other AURKB 77
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC GSK3B 56
CMGC MAPK8 26
Other PLK1 53
AGC PRKCB 342
AGC PRKCE 408
AGC PRKCH 355
CAMK PRKD1 583
STE SLK 34
CAMK STK17B 33
---YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLER-EARICRLL-KHSNIVRLHDSISE------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKCKGAAVKLADFGLAIEV--QGDQQAWFGFAGTPGYLSPEVLR-----KEAYGKPVDIWACGVILYILLVGYPPFW-DE---DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKNLINQMLTINPAKRIT-------AHEALKHPWV--------------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHL-RHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-------LREVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRREIEIQAHL-HHPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLVGNPPFE-SA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-------LAQVSAHPWV--------------
---YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLER-EARICRLL-KHPNIVRLHDSISE------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA-SKSKGAAVKLADFGLAIEV--QGDQQAWFGFAGTPGYLSPEVLR-----KDPYGKPVDMWACGVILYILLVGYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKDLINKMLTINPAKRIT-------ASEALKHPWI--------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIR-EISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELATKKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GKMALNHPYF--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR-EISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AKAALAHPFF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPENI-KK-EICINKML-NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLAGELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-------IPDIKKDRW-Y-------------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------EIKILENLRGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-------AREAMEHPYF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLLGQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-------PLEACAHSFF--------------
---YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPF-QNQTHAKRAYR-ELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVCHKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-------VDEALQHPYI--------------
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQREKMSMEISIHRSL-AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLVGKPPFE-TS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-------INELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-VIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQT------MDRLY--FVMEYVNGG--DLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEIIA-----YQPYGKSVDWWAFGVLLYEMLAGQAPFE-GE---DEDELFQSIMEHNVAYPKSMS---------------------------------------KEAVAICKGLMTKHPGKRLG-------C---------GPEGERDIKEHAFF
--F-NFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDV-ILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQT------KDRLF--FVMEYVNGG--DLMFQIQ----RSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLD-AEGHC---KLADFGMCKEG--ILNGVTTTTFCGTPDYIAPEILQ-----ELEYGPSVDWWALGVLMYEMMAGQPPFE-AD---NEDDLFESILHDDVLYPVWLS---------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------
---FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV-ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQT------PDRLF--FVMEFVNGG--DLMFHIQ----KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD-HEGHC---KLADFGMCKEG--ICNGVTTATFCGTPDYIAPEILQ-----EMLYGPAVDWWAMGVLLYEMLCGHAPFE-AE---NEDDLFEAILNDEVVYPTWLH---------------------------------------EDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPF-F-------------
-PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLR-FPTKQESQLRN-EVAILQNL-HHPGVVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI---IGEKSFRRSVVGTPAYLAPEVLR-----NKGYNRSLDMWSVGVIIYVSLSGTFPFN-ED-----EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS-------VDKTLSHPWL--------------
---WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS-EEELEDYM--V-EIDILASC-DHPNIVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI---KLADFGVSAKN--TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHH-ELNPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDARWT-------TSQLLQHPFV--------------
ILT---SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILH-EIAVLELAKSCPRVINLHEVYEN------TSEII--LILEYAAGG--EIFSLCLP--ELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-SIYPLGDIKIVDFGMSRK---IGHACELREIMGTPEYLAPEILN-----YDPITTATDMWNIGIIAYMLLTHTSPFV-GE---DNQETYLNISQVNVDYSEETFSSVS-----------------------------------QLATDFIQSLLVKNPEKRPT-------AEICLSHSWL--------------
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