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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CAMK2D 203
Other AURKA 133
Other AURKB 77
CAMK CAMK2B 14
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC GSK3B 56
CMGC MAPK14 24
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCH 355
AGC PRKCQ 380
STE SLK 34
CAMK STK17B 33
---YQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKK-LSARDHQKLER-EARICRLL-KHPNIVRLHDSISE------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA-SKSKGAAVKLADFGLAIEV--QGDQQAWFGFAGTPGYLSPEVLR-----KDPYGKPVDMWACGVILYILLVGYPPFW-DE---DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKDLINKMLTINPAKRIT------AS-EALKHPWI--------------
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHL-RHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN---TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM------LR-EVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRREIEIQAHL-HHPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLVGNPPFE-SA---SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSERLP------LA-QVSAHPWV--------------
---YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKK-LSARDHQKLER-EARICRLL-KHSNIVRLHDSISE------EGFHY--LVFDLVTGG--ELFEDIV----AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-SKCKGAAVKLADFGLAIEV--QGDQQAWFGFAGTPGYLSPEVLR-----KEAYGKPVDIWACGVILYILLVGYPPFW-DE---DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKNLINQMLTINPAKRIT------AH-EALKHPWV--------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIR-EISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELATKKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS------GK-MALNHPYF--------------
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR-EISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AK-AALAHPFF--------------
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVDCPENI-KK-EICINKML-NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLAGELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT------IP-DIKKDRW-Y-------------
---YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------EIKILENLRGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AR-EAMEHPYF--------------
---YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLLGQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYR-ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLTGRTLFP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT------AA-QALAHAYF--------------
--F-NFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDV-VIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQT------MDRLY--FVMEYVNGG--DLMYHIQ----QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEN--IWDGVTTKTFCGTPDYIAPEIIA-----YQPYGKSVDWWAFGVLLYEMLAGQAPFE-GE---DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
-FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDV-VLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQT------KDHLF--FVMEFLNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI---KIADFGMCKEN--IFGESRASTFCGTPDYIAPEILQ-----GLKYTFSVDWWSFGVLLYEMLIGQSPFH-GD---DEDELFESIRVDTPHYPRWIT----------------------------------KESKDILEKLFEREPTKRLG-----VTG-NIKIHPFF--------------
---FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDV-ILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQT------PDRLF--FVMEFVNGG--DLMFHIQ----KSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD-HEGHC---KLADFGMCKEG--ICNGVTTATFCGTPDYIAPEILQ-----EMLYGPAVDWWAMGVLLYEMLCGHAPFE-AE---NEDDLFEAILNDEVVYPTWLH----------------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
-FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDV-VLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT------KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI---KIADFGMCKEN--MLGDAKTNTFCGTPDYIAPEILL-----GQKYNHSVDWWSFGVLLYEMLIGQSPFH-GQ---DEEELFHSIRMDNPFYPRWLE----------------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
---WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKS-EEELEDYM--V-EIDILASC-DHPNIVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI---KLADFGVSAKN--TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHH-ELNPMRVLLKIAKSEPPTLAQPSRWS----------------------------------SNFKDFLKKCLEKNVDARWT------TS-QLLQHPFV--------------
ILT---SKELGRGKFAVVRQCISKSTGQEYAAKFLKKRR-RGQDCRAEILH-EIAVLELAKSCPRVINLHEVYEN------TSEII--LILEYAAGG--EIFSLCLP--ELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-SIYPLGDIKIVDFGMSRK---IGHACELREIMGTPEYLAPEILN-----YDPITTATDMWNIGIIAYMLLTHTSPFV-GE---DNQETYLNISQVNVDYSEETFSSVS------------------------------QLATDFIQSLLVKNPEKRPT------AE-ICLSHSWL--------------
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