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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CAMK2G 203
CAMK CAMK2D 14
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
AGC DMPK 81
AGC GRK1 190
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK4 -1
CAMK PHKG1 20
CAMK PIM1 38
CAMK PIM3 40
AGC PRKCD 349
AGC PRKCQ 380
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
STE SLK 34
STE STK10 36
Other TLK2 440
----YQLFEELGKGAFSVV---RRCVK---KTSTQ---EYAAKIINTKKLSARDHQKLER-------EARICRLL-K-----HPN--IVRLHDSISE--------EGFHY--LVFDLVTGG--ELFEDIV----AREYY---SEADASHCIHQILESVNHIHQH--DIVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV-------QGEQQAWFGFAGTPGYLSPEVLR-------KDPYGKPVDIWACGVILYILLVGYPPFWDE----DQHKLYQQIKAGAYDFPSPEWDT-VT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-----AD-QALKHPWV------------
----YQLFEELGKGAFSVV---RRCMK---IPTGQ---EYAAKIINTKKLSARDHQKLER-------EARICRLL-K-----HPN--IVRLHDSISE--------EGFHY--LVFDLVTGG--ELFEDIV----AREYY---SEADASHCIQQILESVNHCHLN--GIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV-------QGDQQAWFGFAGTPGYLSPEVLR-------KDPYGKPVDMWACGVILYILLVGYPPFWDE----DQHRLYQQIKAGAYDFPSPEWDT-VT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-----AS-EALKHPWI------------
----YEKLAKIGQGTFGEV---FKARH---RKTGQ---KVALKKVLMENEKEGFPITALR-------EIKILQLL-K-----HEN--VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKF---TLSEIKRVMQMLLNGLYYIHRN--KILHRDMKAANVLIT-RDGVL----KLADFGLARAFSL---AKNSQPNRYTNRVVTLWYRPPELLL------GERDYGPPIDLWGAGCIMAEMWTRSPIMQGN-TEQHQLALISQLCGSITPEVWPNVDN-YELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SD-DALNHDFF------------
---W-DLVQTLGEGAYGEV---QLAVN---RVTEE---AVAVKIVDMKRAVDCPENI-KK-------EICINKML-N-----HEN--VVKFYGHRRE--------GNIQY--LFLEYCSGG--ELFDRIE----PDIGM---PEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLLLD-ERDNL----KISDFGLATVFR-----YNNRERLLNKMCGTLPYVAPELLK------RREFHAEPVDVWSCGIVLTAMLAGELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI---D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-----IP-DIKKDRW-Y-----------
----FEILKVIGRGAFSEV---AVVKM---KQTGQ---VYAMKIMNKWDMLKRGEVSCFR------EERDVLVNG-D-----RRW--ITQLHFAFQD--------ENYLY--LVMEYYVGG--DLLTLLS---KFGERI---PAEMARFYLAEIVMAIDSVHRL--GYVHRDIKPDNILLD-RCGHI----RLADFGSCLKL------RADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD-STAETYGKIVHYKE---HLSLPLVDEGVP-----------------------------------------------------------------------EEARDFIQRLLCPP-ETRLGR--GGAG-DFRTHPFF------------
FLDF----RVLGKGGFGEV---SACQM---KATGK---LYACKKLNKKRLKKRKGYQGAM------VEKKILMKV-H-----SRF--IVSLAYAFET--------KADLC--LVMTIMNGG--DIRYHIYNVNEENPGF---PEPRALFYTAQIICGLEHLHQR--RIVYRDLKPENVLLD-NDGNV----RISDLGLAVEL-------LDGQSKTKGYAGTPGFMAPELLQ-------GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFS----------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-----FR-D-------ETCDKLRAHPLF
---F-TEFRVLGKGGFGEV---CAVQV---KNTGK---MYACKKLDKKRLKKKGGEKMAL------LEKEILEKV-S-----SPF--IVSLAYAFES--------KTHLC--LVMSLMNGG--DLKFHIYN--VGTRGL---DMSRVIFYSAQIACGMLHLHEL--GIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE--------MKGGKPITQRAGTNGYMAPEILM------EKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF----T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SR-E-------KSDDPR------
----YTDIKVIGNGSFGVV---YQARL---AETRE---LVAIKKVLQDKRFKNR-------------ELQIMRKL-D-----HCN--IVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTI---PILYVKVYMYQLFRSLAYIHSQ--GVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ--------LVRGEPNVSYICSRYYRAPELIF------GATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNP-NYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PL-EACAHSFF------------
----YTDTKVIGNGSFGVV---YQAKL---CDSGE---LVAIKKVLQDKRFKNR-------------ELQIMRKL-D-----HCN--IVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL---PVIYVKLYMYQLFRSLAYIHSF--GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ--------LVRGEPNVSYICSRYYRAPELIF------GATDYTSSIDVWSAGCVLAELLLGQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNP-NYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PL-EACAHSFF------------
----YDIIEVLGKGTFGEV---AKGWR---RSTGE---MVAIKILKNDAYRNRIIKN----------ELKLLHCM-RGLDPEEAH--VIRFLEFFHD--------ALKFY--LVFELLEQ---NLFEFQK-----ENNFAPLPARHIRTVTLQVLTALARLKEL--AIIHADLKPENIMLV-DQTRCPFRVKVIDFGSASIF-------SEVRYVKEPYIQSRFYRAPEILL-------GLPFCEKVDVWSLGCVMAELHLGWPLYPGN-NEYDQVRYICETQGLPKPHLLHAACK-AHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PS-AALRHPFV------------
----YEPKEILGRGVSSVV---RRCIH---KPTSQ---EYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSG-----HPN--IIQLKDTYET--------NTFFF--LVFDLMKRG--ELFDYLT----EKVTL---SEKETRKIMRALLEVICTLHKL--NIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ--------LEPGERLREVCGTPSYLAPEIIECS-MNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR----KQMLMLRMIMSGNYQFGSPEWDD-YS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AE-EALAHPFF------------
----YQVGPLLGSGGFGSV---YSGIR---VSDNL---PVAIKHVEKDRISDWGELPNGTRV---PMEVVLLKKV-S-----SGFSGVIRLLDWFER--------PDSFV--LILERPEPV-QDLFDFIT----ERGAL---QEELARSFFWQVLEAVRHCHNC--GVLHRDIKDENILIDLNRGEL----KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD----------EEIIRGQVFFRQRVS----------------------------------------------------------------------------SECQHLIRWCLALRPSDRPT-----FE-EIQNHPWM------------
----YQVGAVLGSGGFGTV---YAGSR---IADGL---PVAVKHVVKERVTEWGSLGGATV----PLEVVLLRKV-GAA-GGARG--VIRLLDWFER--------PDGFL--LVLERPEPA-QDLFDFIT----ERGAL---DEPLARRFFAQVLAAVRHCHSC--GVVHRDIKDENLLVDLRSGEL----KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR------YHRYHGRSATVWSLGVLLYDMVCGDIPFEQD----------EEILRGRLLFRRRVS----------------------------------------------------------------------------PECQQLIRWCLSLRPSERPS-----LD-QIAAHPWM------------
--FI--FHKVLGKGSFGKV---LLGEL---KGRGE---YFAIKALKKDVVLIDDDVECTM------VEKRVLTLAAE-----NPF--LTHLICTFQT--------KDHLF--FVMEFLNGG--DLMYHIQ----DKGRF---ELYRATFYAAEIMCGLQFLHSK--GIIYRDLKLDNVLLD-RDGHI----KIADFGMCKEN-------IFGESRASTFCGTPDYIAPEILQ-------GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD----DEDELFESIRVDTPHYPRWIT----------------------------------------------------------------------------KESKDILEKLFEREPTKRLG----VTG-NIKIHPFF------------
--FI--LHKMLGKGSFGKV---FLAEF---KKTNQ---FFAIKALKKDVVLMDDDVECTM------VEKRVLSLAWE-----HPF--LTHMFCTFQT--------KENLF--FVMEYLNGG--DLMYHIQ----SCHKF---DLSRATFYAAEIILGLQFLHSK--GIVYRDLKLDNILLD-KDGHI----KIADFGMCKEN-------MLGDAKTNTFCGTPDYIAPEILL-------GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ----DEEELFHSIRMDNPFYPRWLE----------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF------------
----FELLKVLGQGSFGKVFLVRKVTR---PDSGH---LYAMKVLKKATLKVRDRVRTKM-------ERDILADV-N-----HPF--VVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEVMF---TEEDVKFYLAELALGLDHLHSL--GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA-------IDHEKKAYSFCGTVEYMAPEVVN-------RQGHSHSADWWSYGVLMFEMLTGSLPFQGK----DRKETMTLILKAKLGMPQFLS----------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAE-EIKRHV--FY----------
----FELLKVLGQGSYGKV---FLVRK---VKGSDAGQLYAMKVLKKATLKVRDRVRSKM-------ERDILAEV-N-----HPF--IVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEVMF---TEEDVKFYLAELALALDHLHSL--GIIYRDLKPENILLD-EEGHI----KITDFGLSKEA-------IDHDKRAYSFCGTIEYMAPEVVN-------RRGHTQSADWWSFGVLMFEMLTGSLPFQGK----DRKETMALILKAKLGMPQFLS----------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVE-EIKRHPFF------------
----FELLKVLGQGSFGKV---FLVKK---ISGSDARQLYAMKVLKKATLKVRDRVRTKM-------ERDILVEV-N-----HPF--IVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEVMF---TEEDVKFYLAELALALDHLHSL--GIIYRDLKPENILLD-EEGHI----KLTDFGLSKES-------IDHEKKAYSFCGTVEYMAPEVVN-------RRGHTQSADWWSFGVLMFEMLTGTLPFQGK----DRKETMTMILKAKLGMPQFLS----------------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVE-EIKRHSFF------------
----FELLKVLGQGSFGKV---FLVRK---KTGPDAGQLYAMKVLKKASLKVRDRVRTKM-------ERDILVEV-N-----HPF--IVKLHYAFQT--------EGKLY--LILDFLRGG--DVFTRLS----KEVLF---TEEDVKFYLAELALALDHLHQL--GIVYRDLKPENILLD-EIGHI----KLTDFGLSKES-------VDQEKKAYSFCGTVEYMAPEVVN-------RRGHSQSADWWSYGVLMFEMLTGTLPFQGK----DRNETMNMILKAKLGMPQFLS----------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVE-EIKRHLFF------------
----FELLRVLGKGGYGKV---FQVRKVTGANTGK---IFAMKVLKKAMIVRNAKDTAHTK-----AERNILEEV-K-----HPF--IVDLIYAFQT--------GGKLY--LILEYLSGG--ELFMQLE----REGIF---MEDTACFYLAEISMALGHLHQK--GIIYRDLKPENIMLN-HQGHV----KLTDFGLCKES-------IHDGTVTHTFCGTIEYMAPEILM-------RSGHNRAVDWWSLGALMYDMLTGAPPFTGE----NRKKTIDKILKCKLNLPPYLT----------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAG-EVQAHPFF------------
----WEIIGELGDGAFGKV---YKAQN---KETSV---LAAAKVIDTKSEEELEDYM--V-------EIDILASC-D-----HPN--IVKLLDAFYY--------ENNLW--ILIEFCAGG--AVDAVML---ELERPL---TESQIQVVCKQTLDALNYLHDN--KIIHRDLKAGNILFT-LDGDI----KLADFGVSAKN-------TRTIQRRDSFIGTPYWMAPEVVMCE--TSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL-NPMRVLLKIAKSEPPTLAQPSRWS----------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TS-QLLQHPFV------------
----WEIVGELGDGAFGKV---YKAKN---KETGA---LAAAKVIETKSEEELEDYI--V-------EIEILATC-D-----HPY--IVKLLGAYYH--------DGKLW--IMIEFCPGG--AVDAIML---ELDRGL---TEPQIQVVCRQMLEALNFLHSK--RIIHRDLKAGNVLMT-LEGDI----RLADFGVSAKN-------LKTLQKRDSFIGTPYWMAPEVVMCE--TMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL-NPMRVLLKIAKSDPPTLLTPSKWS----------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS-----AA-QLLEHPFV------------
--YL--LLHLLGRGGFSEV---YKAFD---LTEQR---YVAVKIHQLNKNWRDEKKENYHKH--ACREYRIHKEL-D-----HPR--IVKLYDYFSL-------DTDSFC--TVLEYCEGN--DLDFYLK----QHKLM---SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV-NGTACG-EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVV---GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHN--QSQQDILQENTILKATEVQFPPKPV-VT-----------------------------------------------------------------------PEAKAFIRRCLAYRKEDRID-----VQ-QLACDPYL------------
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