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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKB 77
CMGC CDC2 4
TK FES 561
TK PTK2 422
-FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDTETEGV--PSTAIR-EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-FEIGRPLGKGKFGNVYLAREK---KSHFIVALKVLFKSQIEKEG--VEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQ---KSC--TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV---HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV
-YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLESEEEGV--PSTAIR-EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
L-VLGEQIGRGNFGEVFSGRLR---ADNTLVAVKSCR-ETLP-PDLKAKFL-Q-EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLR----TEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEAD--GVYAASGGLRQVPVKWTAPEALN-YGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP----------------------------DAVFRLMEQCWAYEPGQRPSFSTIYQEL--
-IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTS-DSVREKFL-Q-EALTMRQFDHPHIVKLIGVIT-ENPVWIIMELCTLGELRSFLQ----VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-E--DSTYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
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